Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation.
Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation.
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DOI：
10.1111/ejh.12319
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发表时间：
2014-08
影响因子：
3.1
通讯作者：
Prinzen L
中科院分区：
文献类型：
--
作者：
van der Linden N;Klinkenberg LJ;Meex SJ;Beckers EA;de Wit NC;Prinzen L
一段时期的血小板减少是常见的干细胞移植后（SCT）。为了防止严重的出血并发症，预防性输血小板。先前的研究表明，未成熟血小板的增加先于血小板计数的恢复。我们的目的是确定未成熟血小板在2天内预测血小板生成恢复的临界值。血液学参数在Sysmex XN血细胞计上测量。我们计算了8名健康人的血小板参考变化值（RCV）作为血小板恢复的标志。为了确定截断值，我们使用16例自体SCT患者的数据进行了ROC分析。血小板浓度的RCV为14.1%。SCT后13天（中位范围9-31天）观察血小板恢复。在所有自体SCT患者中，血小板恢复前未成熟血小板分数（IPF）均有所增加。2 d内血小板恢复的最佳临界值IPF为5.3%（特异性0.98，敏感性0.47，阳性预测值0.93）。我们确定了一个最佳临界值，IPF为5.3%，用于预测自体SCT术后2天内的血小板恢复。在输血策略中实施这个临界值可能会减少预防性血小板输注的次数。
A period of thrombocytopenia is common after stem cell transplantation (SCT). To prevent serious bleeding complications, prophylactic platelet transfusions are administered. Previous studies have shown that a rise in immature platelets precedes recovery of platelet count. Our aim was to define a cutoff value for immature platelets predicting thrombopoietic recovery within 2 d. Hematological parameters were measured on the Sysmex XN hemocytometer. We calculated reference change values (RCV) for platelets in eight healthy individuals as marker for platelet recovery. To define a cutoff value, we performed ROC analysis using data from 16 autologous SCT patients. RCV for platelet concentration was 14.1%. Platelet recovery was observed 13 (median; range 9–31) days after SCT. Increase in immature platelet fraction (IPF) before platelet recovery was seen in all autologous SCT patients. Optimal cutoff IPF was found to be 5.3% for platelet recovery within 2 d (specificity 0.98, sensitivity 0.47, positive predictive value 0.93). We identified an optimal cutoff value for IPF 5.3% to predict platelet recovery after autologous SCT within 2 d. Implementing this cutoff value in transfusion strategy may reduce the number of prophylactic platelet transfusions.
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影响因子：
0.9
作者：
Goncalo, A. P.;Barbosa, I. L.;Mendes, C.
通讯作者：
Mendes, C.
影响因子：
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作者：
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DOI：
10.1111/j.1751-553x.2007.00993.x
发表时间：
2008-12-01
影响因子：
3
作者：
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作者：
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通讯作者：
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影响因子：
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作者：
Bat T;Leitman SF;Calvo KR;Chauvet D;Dunbar CE
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