Probing perceptual decisions in rodents.

Probing perceptual decisions in rodents.
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DOI:
10.1038/nn.3410
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发表时间:
2013-07
影响因子:
25
通讯作者:
Churchland, Anne K.
Churchland, Anne K.
中科院分区:
医学1区
文献类型:
--
作者:
Carandini, Matteo;Churchland, Anne K.

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知觉决策的研究让我们深入了解大脑如何利用复杂的、有时是模糊的信息来指导行动。要理解其潜在过程及其神经基础,就需要将神经活动的记录和操纵与严格的心理物理学相结合。尽管这项研究传统上是在灵长类动物中进行的,但至少部分在小鼠和大鼠中进行这项研究似乎越来越有前景。然而,针对这些啮齿动物的严格的心理物理学方法还没有像针对灵长类动物的方法那样完善。在这里,我们简要概述啮齿动物的感觉能力以及它们专门用于感觉和决策的皮质区域。然后我们回顾心理物理学的方法,重点关注在啮齿动物中实施这些方法时出现的技术问题。这些方法带来了一系列丰富的挑战和机遇。
The study of perceptual decision-making offers insight into how the brain uses complex, sometimes ambiguous information to guide actions. Understanding the underlying processes and their neural bases requires that one pair recordings and manipulations of neural activity with rigorous psychophysics. Though this research has been traditionally performed in primates, it seems increasingly promising to pursue it at least partly in mice and rats. However, rigorous psychophysical methods are not yet as developed for these rodents as they are for primates. Here we give a brief overview of the sensory capabilities of rodents and of their cortical areas devoted to sensation and decision. We then review methods of psychophysics, focusing on the technical issues that arise in their implementation in rodents. These methods represent a rich set of challenges and opportunities.
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