Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection.
Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection.
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DOI：
10.1016/j.jlr.2021.100061
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发表时间：
2021
影响因子：
6.5
通讯作者：
Allayee H
中科院分区：
文献类型：
--
作者：
Hilser JR;Han Y;Biswas S;Gukasyan J;Cai Z;Zhu R;Tang WHW;Deb A;Lusis AJ;Hartiala JA;Allayee H
具有代谢综合征特征的个体特别容易感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2），这是一种与严重呼吸道疾病2019冠状病毒病（COVID-19）相关的新型冠状病毒。尽管人们对COVID-19给予了相当大的关注，但代谢综合征与SARS-CoV-2感染之间的联系仍不清楚。利用英国生物银行的数据，我们研究了COVID-19的严重程度与SARS-CoV-2感染前测量的代谢综合征相关血清生物标志物之间的关系。Logistic回归分析用于检测SARS-CoV-2相关结果的生物标志物水平和生物标志物相关遗传变异。在SARS-CoV-2阳性病例和阴性对照组中，校正年龄、性别、肥胖、高血压、2型糖尿病和冠状动脉疾病后，血清HDL-胆固醇或载脂蛋白A1水平升高10 mg/dl与SARS-CoV-2感染风险降低10%相关。对HDL-胆固醇已知遗传变异的评估显示，与载脂蛋白E3纯合子相比，载脂蛋白E4等位基因纯合子个体感染SARS-CoV-2或因COVID-19死亡的风险高出0.02至3倍，即使在调整HDL-胆固醇水平后。然而，所有评估的HDL-胆固醇升高等位基因的累积效应和孟德尔随机化分析并未显示遗传性高HDL-胆固醇水平与SARS-CoV-2感染风险降低之间的关联。这些结果表明，在SAR-CoV-2暴露前测量的血清HDL-胆固醇和载脂蛋白A1水平是严重COVID-19感染的临床风险因素，但没有提供证据表明遗传性升高的HDL-胆固醇水平与SAR-CoV-2感染相关。
Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus associated with the severe respiratory disease, coronavirus disease 2019 (COVID-19). Despite considerable attention dedicated to COVID-19, the link between metabolic syndrome and SARS-CoV-2 infection remains unclear. Using data from the UK Biobank, we investigated the relationship between severity of COVID-19 and metabolic syndrome-related serum biomarkers measured prior to SARS-CoV-2 infection. Logistic regression analyses were used to test biomarker levels and biomarker-associated genetic variants with SARS-CoV-2-related outcomes. Among SARS-CoV-2-positive cases and negative controls, a 10 mg/dl increase in serum HDL-cholesterol or apolipoprotein A1 levels was associated with ∼10% reduced risk of SARS-CoV-2 infection, after adjustment for age, sex, obesity, hypertension, type 2 diabetes, and coronary artery disease. Evaluation of known genetic variants for HDL-cholesterol revealed that individuals homozygous for apolipoprotein E4 alleles had ∼2- to 3-fold higher risk of SARS-CoV-2 infection or mortality from COVID-19 compared with apolipoprotein E3 homozygotes, even after adjustment for HDL-cholesterol levels. However, cumulative effects of all evaluated HDL-cholesterol-raising alleles and Mendelian randomization analyses did not reveal association of genetically higher HDL-cholesterol levels with decreased risk of SARS-CoV-2 infection. These results implicate serum HDL-cholesterol and apolipoprotein A1 levels measured prior to SAR-CoV-2 exposure as clinical risk factors for severe COVID-19 infection but do not provide evidence that genetically elevated HDL-cholesterol levels are associated with SAR-CoV-2 infection.
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影响因子：
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