Hippocampal-prefrontal dynamics in spatial working memory: interactions and independent parallel processing.
Hippocampal-prefrontal dynamics in spatial working memory: interactions and independent parallel processing.
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DOI：
10.1016/j.bbr.2011.07.045
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发表时间：
2011-12-01
影响因子：
2.7
通讯作者：
Kesner RP
中科院分区：
文献类型：
--
作者：
Churchwell JC;Kesner RP
内存进程可以是独立的、竞争的、并行操作的或交互的。根据这一观点，行为研究表明，海马体（HPC）和前额叶皮层（PFC）可能作为一个集成电路在执行任务，需要工作记忆在较长的延迟，而在短的延迟HPC和PFC可能并行操作或具有完全分离的功能。在本研究中，我们测试了大鼠在空间延迟非匹配样本工作记忆任务使用短时间和长时间延迟，以评估假设的中间CA1区的HPC（iCA1）和内侧PFC（mPFC）的相互作用，并在不同的时间工作记忆的限制下并行操作。为了评估这些结构的功能作用，我们使用了一种失活策略，其中每例受试者接受了iCA 1和mPFC的双侧慢性插管植入，使我们能够对每例受试者的结构和结构对进行双侧、对侧、同侧和组合双侧失活。这种新的方法使我们能够测试电路级系统的相互作用，以及独立的并行处理，而我们同时参数化地操纵任务的时间维度。目前的研究结果表明，在较长的延迟，iCA1和mPFC相互作用，以协调回顾性和前瞻性的记忆过程中，预期获得一个远程目标，而在短的延迟，无论是结构可以独立地代表空间信息足以成功地完成任务。
Memory processes may be independent, compete, operate in parallel, or interact. In accordance with this view, behavioral studies suggest that the hippocampus (HPC) and prefrontal cortex (PFC) may act as an integrated circuit during performance of tasks that require working memory over longer delays, whereas during short delays the HPC and PFC may operate in parallel or have completely dissociable functions. In the present investigation we tested rats in a spatial delayed non-match to sample working memory task using short and long time delays to evaluate the hypothesis that intermediate CA1 region of the HPC (iCA1) and medial PFC (mPFC) interact and operate in parallel under different temporal working memory constraints. In order to assess the functional role of these structures, we used an inactivation strategy in which each subject received bilateral chronic cannula implantation of the iCA1 and mPFC, allowing us to perform bilateral, contralateral, ipsilateral, and combined bilateral inactivation of structures and structure pairs within each subject. This novel approach allowed us to test for circuit-level systems interactions, as well as independent parallel processing, while we simultaneously parametrically manipulated the temporal dimension of the task. The current results suggest that, at longer delays, iCA1 and mPFC interact to coordinate retrospective and prospective memory processes in anticipation of obtaining a remote goal, whereas at short delays either structure may independently represent spatial information sufficient to successfully complete the task.
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DOI：
10.1590/s0100-879x2000000900002
发表时间：
2000-09-01
影响因子：
2.3
作者：
Baddeley, A;Bueno, O;Da Cunha, C
通讯作者：
Da Cunha, C
DOI：
10.1016/s0163-1047(05)80065-2
发表时间：
1994-03-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
CHIBA, AA;KESNER, RP;REYNOLDS, AM
通讯作者：
REYNOLDS, AM
影响因子：
1.9
作者：
COLOMBO, M;GROSS, CG
通讯作者：
GROSS, CG
影响因子：
2.9
作者：
Constantinidis, Christos;Procyk, Emmanuel
通讯作者：
Procyk, Emmanuel
影响因子：
14.5
作者：
ETTLINGER, G
通讯作者：
ETTLINGER, G