Radioprotective effects of gallic acid in mice.
Radioprotective effects of gallic acid in mice.
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DOI：
10.1155/2013/953079
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发表时间：
2013
影响因子：
--
通讯作者：
Nair CK
中科院分区：
文献类型：
--
作者：
Nair GG;Nair CK
研究了天然多酚没食子酸（3，4，5-三羟基苯甲酸，GA）对瑞士白化病小鼠的辐射防护能力。在全身γ辐射暴露（2-8戈伊; 6只动物/组）前1小时口服给予GA（100 mg/kg体重），如彗星试验所揭示的，减少了辐射诱导的小鼠外周血白细胞、骨髓细胞和脾细胞中的细胞DNA损伤。GA管理还防止辐射诱导的抗氧化酶，谷胱甘肽过氧化物酶（GPx），和非蛋白巯基谷胱甘肽（GSH）的水平下降，并抑制这些动物的膜脂质过氧化。小鼠全身γ辐射暴露也导致血液网织红细胞微核形成和骨髓细胞染色体畸变，GA给药导致微核形成和染色体畸变抑制。在辐射的动物，GA的管理引起的DNA修复过程中的速度的增强和内源性脾集落形成的显着增加。GA的施用还防止暴露于致死剂量（10戈伊）的γ辐射的动物（10只动物/组）中的辐射诱导的体重减轻和死亡。(For每个实验中，未给予GA的未辐照动物作为正常对照;未给予GA的特定剂量（戈伊）辐照动物作为辐照对照;未辐照GA处理的动物作为单独药物对照）。
Radioprotecting ability of the natural polyphenol, gallic acid (3,4,5-trihydroxybenzoic acid, GA), was investigated in Swiss albino mice. Oral administration of GA (100 mg/kg body weight), one hour prior to whole body gamma radiation exposure (2–8 Gy; 6 animals/group), reduced the radiation-induced cellular DNA damage in mouse peripheral blood leukocytes, bone marrow cells, and spleenocytes as revealed by comet assay. The GA administration also prevented the radiation-induced decrease in the levels of the antioxidant enzyme, glutathione peroxidise (GPx), and nonprotein thiol glutathione (GSH) and inhibited the peroxidation of membrane lipids in these animals. Exposure of mice to whole body gamma radiation also caused the formation of micronuclei in blood reticulocytes and chromosomal aberrations in bone marrow cells, and the administration of GA resulted in the inhibition of micronucleus formation and chromosomal aberrations. In irradiated animals, administration of GA elicited an enhancement in the rate of DNA repair process and a significant increase in endogenous spleen colony formation. The administration of GA also prevented the radiation-induced weight loss and mortality in animals (10 animals/group) exposed to lethal dose (10 Gy) of gamma radiation. (For every experiment unirradiated animals without GA administration were taken as normal control; specific dose (Gy) irradiated animals without GA administration serve as radiation control; and unirradiated GA treated animals were taken as drug alone control).
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DOI：
10.1016/s0165-1110(96)90037-8
发表时间：
1996-11-01
期刊：
MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY
影响因子：
--
作者：
Muller, WU;Nusse, M;Streffer, C
通讯作者：
Streffer, C
影响因子：
5.1
作者：
Abdelwahed, Afef;Bouhlel, Ines;Chekir-Ghedira, Leila
通讯作者：
Chekir-Ghedira, Leila
影响因子：
5.9
作者：
GRDINA, DJ;SIGDESTAD, CP
通讯作者：
SIGDESTAD, CP
DOI：
10.1016/s0921-8777(98)00061-5
发表时间：
1999-01-26
期刊：
MUTATION RESEARCH-DNA REPAIR
影响因子：
--
作者：
Mendiola-Cruz, MT;Morales-Ramírez, P
通讯作者：
Morales-Ramírez, P
影响因子：
3.4
作者：
Cromheecke, M;Piers, BA;Hoekstra, HJ
通讯作者：
Hoekstra, HJ