The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study.
The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study.
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DOI：
10.1007/s10654-013-9767-1
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发表时间：
2013-01
影响因子：
13.6
通讯作者：
Leitzmann, Michael F.
中科院分区：
文献类型：
--
作者：
Behrens, Gundula;Matthews, Charles E.;Moore, Steven C.;Freedman, Neal D.;McGlynn, Katherine A.;Everhart, James E.;Hollenbeck, Albert R.;Leitzmann, Michael F.
尽管体育锻炼对肝胆癌有潜在的预防作用，但关于两者之间的关系的信息很少。我们在NIH-AARP饮食与健康研究的507897名参与者中研究了剧烈运动频率与肝胆癌之间的关系，这些参与者在1995/1996年的基线年龄为50岁至71岁。随访10年，共登记肝癌628例，肝外胆道癌317例。根据每周从事剧烈体力活动20分钟或以上的频率来分配体力活动水平：从不/很少(最低水平)、每周不到一次、每周1~2次、每周3~4次、每周5次或更多(最高水平)。COX回归分析显示，体力活动水平最高和最低的多变量调整相对危险度(RR=0.64，95%可信区间(CI)=0.49-0.84，p-趋势和t；0.001)，特别是肝细胞癌(RR=0.56，95%CI=0.41-0.78，p-趋势和t；0.001)，与体重指数无关。多因素分析显示，体力活动与肝外胆管癌(RR=0.86，95%CI=0.45~1.65)、壶腹癌(RR=0.66，95%CI=0.29~1.48)、胆囊癌(RR=0.63，95%CI=0.33~1.21)无统计学意义。这些结果表明，体育锻炼对肝癌有潜在的预防作用，但与体重指数无关，对肝外胆道癌没有预防作用。
Despite a potential preventive effect of physical activity on hepatobiliary cancer, little information is available on the relation between the two. We studied the association between frequency of vigorous physical activity and hepatobiliary cancer among 507,897 participants of the NIH-AARP Diet and Health Study, aged 50 to 71 years at baseline in 1995/1996. During ten years of follow-up, 628 incident cases of liver cancer and 317 cases of extrahepatic biliary tract cancer were registered. Physical activity levels were assigned according to the frequency of engagement in 20 minutes or more of vigorous physical activity per week: never/rarely (lowest level), less than once per week, 1 to 2 times per week, 3 to 4 times per week, 5 or more times per week (highest level). Using Cox regression, multivariate-adjusted relative risks (RR) comparing the highest with the lowest level of physical activity revealed a statistically significant decreased risk for liver cancer (RR=0.64, 95% confidence interval (CI)=0.49–0.84, p-trend<0.001), particularly hepatocellular carcinoma (RR=0.56, 95% CI=0.41–0.78, p-trend<0.001), independent of body mass index. By comparison, multivariate analyses indicated that physical activity was not statistically significantly associated with extrahepatic bile duct cancer (RR=0.86, 95% CI=0.45–1.65), ampulla of Vater cancer (RR=0.66, 95% CI=0.29–1.48), or gallbladder cancer (RR=0.63, 95% CI=0.33–1.21). These results suggest a potential preventive effect of physical activity on liver cancer but not extrahepatic biliary tract cancer, independent of body mass index.
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影响因子：
8.8
作者：
Kurahashi, N.;Inoue, M.;Iwasaki, M.;Tanaka, Y.;Mizokami, M.;Tsugane, S.
通讯作者：
Tsugane, S.
影响因子：
5
作者：
Inoue, Manami;Yamamoto, Seiichiro;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
DOI：
10.1007/978-3-642-03503-6_8
发表时间：
2011-01-01
期刊：
INFLAMMATION AND GASTROINTESTINAL CANCERS
影响因子：
--
作者：
Alison, Malcolm R.;Nicholson, Linda J.;Lin, Wey-Ran
通讯作者：
Lin, Wey-Ran
影响因子：
2
作者：
GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
16.2
作者：
Kang, J;Robertson, RJ;Utter, AC
通讯作者：
Utter, AC