The Risk of Fasting Triglycerides and its Related Indices for Ischemic Cardiovascular Diseases in Japanese Community Dwellers: the Suita Study.
The Risk of Fasting Triglycerides and its Related Indices for Ischemic Cardiovascular Diseases in Japanese Community Dwellers: the Suita Study.
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DOI：
10.5551/jat.62730
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发表时间：
2021-12-01
影响因子：
4.4
通讯作者：
Miyamoto Y
中科院分区：
文献类型：
--
作者：
Higashiyama A;Wakabayashi I;Okamura T;Kokubo Y;Watanabe M;Takegami M;Honda-Kohmo K;Okayama A;Miyamoto Y
目标：在日本城市普通人群中进行了一项前瞻性队列研究，以调查亚洲社区居民中甘油三酯（TG）及其相关指标是否与调整低密度脂蛋白胆固醇（LDL-C）后缺血性心血管疾病（CVD）发病风险相关。 研究方法：在6，684名年龄在30-79岁、无CVD病史且空腹TG水平<400 mg/dL的日本社区居民中进行了一项为期15.1年的前瞻性队列研究。校正包括LDL-C在内的协变量后，估计缺血性CVD发生率的多变量校正风险比（HR）和TG十分位数（D）的95%置信区间（CI）以及根据LDL-C水平（≥ 140和<140 mg/dL）的对数转换TG的1-标准差（SD）增量（TG的1-SD）的95%置信区间（CI）。还估计了缺血性CVD的TG、TG/HDL-C和心脏代谢指数（CMI）的五分位数（Q）的多变量校正HR和95%CI。 结果：在101,230人年中，发生了464例缺血性CVD病例。TG D10的HR（95%CI）为1.56（1.05-2.32），TG 1-SD的HR（95%CI）为1.30（1.00-1.70）（LDL-C <140 mg/dL）和1.07（0.77-1.50）（LDL-C ≥ 140 mg/dL）。CMI Q5的多变量校正HR高于TG和TG/HDL-C。 结论：在TG <400 mg/dL的日本社区居民中，调整LDL-C后，空腹TG是缺血性CVD发病率的独立预测因子。在TG、TG/HDL-C和CMI中，CMI可能是缺血性CVD最有力的预测因子。
Aim: A prospective cohort study in a Japanese urban general population was performed to investigate whether triglyceride (TG) and its related indices were associated with the risk for the incidence of ischemic cardiovascular disease (CVD) after the adjustment for low-density lipoprotein cholesterol (LDL-C) in Asian community dwellers. Methods: A 15.1-year prospective cohort study was performed in 6,684 Japanese community dwellers aged 30–79 years without a history of CVD and whose fasting TG levels were ＜400 mg/dL. After adjusting for covariates, including LDL-C, the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of the deciles (D) of TG and those of 1-standard deviation (SD) increment of log-transformed TG (1-SD of TG) according to LDL-C level (≥ 140 and ＜140 mg/dL) for ischemic CVD incidence were estimated. The multivariable-adjusted HRs and 95%CIs of the quintiles (Q) of TG, TG/HDL-C, and the cardiometabolic index (CMI) for ischemic CVD were also estimated. Results: In 101,230 person-years, 464 ischemic CVD cases occurred. For D 10 of TG, the HR (95%CI) was 1.56 (1.05–2.32), and for 1-SD of TG, it was 1.30 (1.00–1.70) in participants with LDL-C ＜140 mg/dL and 1.07 (0.77–1.50) in those with LDL-C ≥ 140 mg/dL. For Q 5 of the CMI, the multivariable-adjusted HR was higher than those of TG and TG/HDL-C. Conclusions: Fasting TG was an independent predictor for ischemic CVD incidence after adjusting for LDL-C in Japanese community dwellers with TG ＜400 mg/dL. Among TG, TG/HDL-C, and the CMI, the CMI could be the most powerful predictor for ischemic CVD.
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影响因子：
4.7
作者：
Tatsumi Y;Watanabe M;Kokubo Y;Nishimura K;Higashiyama A;Okamura T;Okayama A;Miyamoto Y
通讯作者：
Miyamoto Y
影响因子：
2.1
作者：
Kahn HS
通讯作者：
Kahn HS
影响因子：
5.4
作者：
Kokubo Y;Watanabe M;Higashiyama A;Nakao YM;Nakamura F;Miyamoto Y
通讯作者：
Miyamoto Y
影响因子：
37.8
作者：
Patel, A;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.