Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly.
Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly.
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DOI：
10.1016/j.biopsych.2009.08.024
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发表时间：
2010-03-15
影响因子：
10.6
通讯作者：
Mintun MA
中科院分区：
文献类型：
--
作者：
Sheline YI;Raichle ME;Snyder AZ;Morris JC;Head D;Wang S;Mintun MA
在阿尔茨海默病（AD）中，“默认模式网络”（DMN）内的重要功能连接被破坏，这可能来自淀粉样蛋白β（Aβ）斑块相关的神经元毒性。在这里，我们试图通过检查有和没有临床前淀粉样蛋白沉积的认知正常参与者的功能连接来确定即使在没有任务的情况下是否也可以看到Aβ淀粉样蛋白斑块的病理影响。将阿尔茨海默病（AD）参与者（n= 35）与68名认知正常的参与者进行比较，这些参与者通过PET PIB成像进一步细分为没有脑淀粉样蛋白（PIB-）证据和脑淀粉样蛋白（PIB+）沉积的参与者。静息状态fMRI显示，与PIB−组相比，PIB+组楔前叶与海马、海马旁、前扣带回、背扣带回、直回、上级楔前叶和视皮层的功能连接存在显著差异。这些差异与AD组中的差异在相同的区域和方向上。因此，在认知或行为变化的任何表现之前，在具有脑淀粉样蛋白沉积的认知正常受试者中存在静息状态连接的差异，这表明可以使用静息状态fMRI检测Aβ毒性的早期表现。
Important functional connections within the “default mode network” (DMN) are disrupted in Alzheimer’s disease (AD), likely from amyloid-beta (Aβ) plaque-associated neuronal toxicity. Here we sought to determine if pathological effects of Aβ amyloid plaques could be seen even in the absence of a task by examining functional connectivity in cognitively normal participants with and without preclinical amyloid deposition. Participants with Alzheimer’s disease (AD) (n= 35) were compared with 68 cognitively normal participants who were further subdivided by PET PIB imaging into those without evidence of brain amyloid (PIB−) and those with brain amyloid (PIB+) deposition. Resting state fMRI demonstrated that, compared with the PIB− group, the PIB+ group differed significantly in functional connectivity of the precuneus to hippocampus, parahippocampus, anterior cingulate, dorsal cingulate, gyrus rectus, superior precuneus and visual cortex. These differences were in the same regions, and in the same direction, as differences found in the AD group. Thus, prior to any manifestations of cognitive or behavioral changes there were differences in resting state connectivity in cognitively normal subjects with brain amyloid deposition, suggesting that early manifestation of Aβ toxicity can be detected using resting state fMRI.
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影响因子：
--
作者：
Roe, Catherine M.;Mintun, Mark A.;D'Angelo, Gina;Xiong, Chengjie;Grant, Elizabeth A.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
5.7
作者：
Van Essen, DC
通讯作者：
Van Essen, DC
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
16.2
作者：
Sperling, Reisa A.;LaViolette, Peter S.;O'Keefe, Kelly;O'Brien, Jacqueline;Rentz, Dorene M.;Pihlajamaki, Maija;Marshall, Gad;Hyman, Bradley T.;Selkoe, Dennis J.;Hedden, Trey;Buckner, Randy L.;Becker, J. Alex;Johnson, Keith A.
通讯作者：
Johnson, Keith A.
影响因子：
9.9
作者：
Storandt, M;Grant, EA;Morris, JC
通讯作者：
Morris, JC