Chikungunya virus vector competency of Brazilian and Florida mosquito vectors.
Chikungunya virus vector competency of Brazilian and Florida mosquito vectors.
复制标题
DOI：
10.1371/journal.pntd.0006521
复制
发表时间：
2018-06
影响因子：
3.8
通讯作者：
Alto BW
中科院分区：
文献类型：
--
作者：
Honório NA;Wiggins K;Câmara DCP;Eastmond B;Alto BW
基孔肯雅病毒是一种媒介传播的甲病毒，通过被感染的雌性Ae叮咬传播。埃及伊蚊和埃及伊蚊。白纹伊蚊在巴西，2014年至2016年期间报告了近32万例本土人类病例，在佛罗里达，许多输入性CHIKV病毒血症病例（> 3，800例）表明建立本地传播的潜在高风险。在本研究中，我们进行了一系列的实验，以确定不同的巴西和佛罗里达人口的Ae的病毒传播和传播率。埃及伊蚊和埃及伊蚊。对于CHIKV的出现的亚洲基因型，在感染后2、5和13天观察白纹伊蚊。我们的研究结果表明，所有的测试群体的Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊在接触后2天内就有很高比例（> 0.80）的个体发生播散性感染。我们发现蚊子种群来源对病毒传播率的影响没有显着的治疗效果。传播率有一个异质性的模式，与美国AE。埃及伊蚊和巴西伊蚊白纹伊蚊的成功感染率最高（早在感染后2天分别为0.50和0.82）。模型结果发现，人口来源，人口来源x物种，人口来源x天后感染和人口来源x物种x天后感染的显着影响。基孔肯雅热在世界上许多热带和亚热带国家被认为是一种严重的蚊媒疾病。它在巴西已经是一种流行病，在佛罗里达也是一种潜在的风险。它主要由埃及伊蚊和白纹伊蚊传播。这些蚊子种类在巴西和佛罗里达一年中的大部分时间都很常见。在这项研究中，我们确定了两个组成部分的载体能力从巴西和佛罗里达人口的蚊子的新兴亚洲基因型基孔肯雅病毒：病毒传播和传播率。两种伊蚊种群在摄入基孔肯雅病毒感染的血液后两天就表现出高比例的播散性感染。Ae.来自佛罗里达和Ae.产于巴西的白纹伊蚊。我们的研究结果表明，蚊子病毒相互作用的两个Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊可能因地理种群而异，这可能影响公共卫生措施，在这种虫媒病毒疾病暴发期间应予以考虑。
Chikungunya virus is a vector-borne alphavirus transmitted by the bites of infected female Ae. aegypti and Ae. albopictus. In Brazil between 2014 and 2016 almost 320 thousand autochthonous human cases were reported and in Florida numerous imported CHIKV viremic cases (> 3,800) demonstrate the potential high risk to establishment of local transmission. In the present study, we carried out a series of experiments to determine the viral dissemination and transmission rates of different Brazilian and Florida populations of Ae. aegypti and Ae. albopictus at 2, 5, and 13 days post-infection for the emergent Asian genotype of CHIKV. Our results show that all tested populations of Ae. aegypti and Ae. albopictus have a high proportion (> 0.80) of individuals with disseminated infection as early as 2 days-post exposure. We found no significant treatment effects of mosquito population origin effects on viral dissemination rates. Transmission rates had a heterogeneous pattern, with US Ae. aegypti and Brazilian Ae. albopictus having the highest proportion of individuals with successful infection (respectively 0.50 and 0.82 as early as 2 days-post infection). Model results found significant effects of population origin, population origin x species, population origin x days post-infection and population origin x species x days post infection. Chikungunya is considered a serious mosquito-borne disease in many tropical and subtropical countries throughout the world. It is already an epidemic disease in Brazil and poses as a potential risk in Florida. It is mainly transmitted by mosquitoes Aedes aegypti and Aedes albopictus. These mosquito species are common and abundant throughout much of the year in Brazil and Florida. In this study, we determined two components of vector competence from Brazilian and Florida populations of both mosquitoes to the emergent Asian genotype of chikungunya virus: viral dissemination and transmission rates. Both Aedes populations exhibited a high proportion of disseminated infection as early as two days after ingestion of chikungunya virus infected blood. Transmission efficiency was higher in Ae. aegypti from Florida and Ae. albopictus from Brazil. Our findings suggest that mosquito-virus interactions of both Ae. aegypti and Ae. albopictus may vary by geographic population, which may impact public health measures and should be considered during outbreaks of this arboviral disease.
登录
查看更多内容
影响因子：
2.1
作者：
Braks, MAH;Honório, NA;Lounibos, LP
通讯作者：
Lounibos, LP
影响因子：
6.7
作者：
Lefèvre T;Vantaux A;Dabiré KR;Mouline K;Cohuet A
通讯作者：
Cohuet A
影响因子：
2.7
作者：
Juliano, SA;Lounibos, LP;O'Meara, GF
通讯作者：
O'Meara, GF
影响因子：
3.3
作者：
Alto, Barry W.;Bettinardi, David
通讯作者：
Bettinardi, David
影响因子：
2.1
作者：
Alto, Barry W.;Wiggins, Keenan;Lounibos, L. Philip
通讯作者：
Lounibos, L. Philip