A translational approach to vocalization deficits and neural recovery after behavioral treatment in Parkinson disease.
A translational approach to vocalization deficits and neural recovery after behavioral treatment in Parkinson disease.
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DOI：
10.1016/j.jcomdis.2010.04.004
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发表时间：
2010-07
影响因子：
1.7
通讯作者：
Connor, Nadine P.
中科院分区：
文献类型：
--
作者：
Ciucci, Michelle R.;Vinney, Lisa;Wahoske, Emerald J.;Connor, Nadine P.
帕金森病以复杂的神经病理特征为特征，主要影响基底神经节中的多巴胺能神经通路，包括调节颅感觉运动功能（如吞咽、声音和言语）的通路。我们实验室之前的工作表明，单侧6-羟多巴胺输注到内侧前脑束的大鼠模型对研究肢体感觉运动缺陷很有用，也会产生发声缺陷，这可能可以通过强化运动来治疗。这为我们提供了一个机会来探索行为和神经恢复的潜在机制，因为干预与帕金森病（PD）相关的颅感觉运动缺陷。我们的方法包括记录和声学分析雄性大鼠在控制条件下、神经毒素输注后（帕金森病模型）和有针对性的发声训练后的超声波发声。我们还使用完善的行为和免疫组织化学方法来评估干预后基底神经节纹状体的神经化学恢复水平。我们的发现虽然是初步的，但也促使我们在纹状体之外的其他大脑区域寻找潜在的恢复机制。因此，我们未来的工作将集中在PD模型中行为恢复的潜在机制上，希望这将有助于提高对大脑功能的理解，并改善对声音和吞咽障碍的治疗。
Parkinson disease is characterized by a complex neuropathological profile that primarily affects dopaminergic neural pathways in the basal ganglia, including pathways that modulate cranial sensorimotor functions such as swallowing, voice and speech. Prior work in our lab has shown that the rat model of unilateral 6-hydroxydopamine infusion to the medial forebrain bundle that has been useful for studying limb sensorimotor deficits also yields vocalization deficits that may be amenable to treatment with intensive exercise. This affords us an opportunity to explore the potential mechanisms underlying behavioral and neural recovery as a result of intervention for cranial sensorimotor deficits associated with Parkinson disease (PD). Our methods include recording and acoustic analysis of male rat ultrasonic vocalizations in a control condition, after neurotoxin infusion (Parkinson disease model), and after targeted vocalization training. We also use well-established behavioral and immunohistochemical methods to assess the level of neurochemical recovery in the striatum of the basal ganglia after our interventions. Our findings, although preliminary, prompt us to look in other brain regions extraneous to the striatum for potential underlying mechanisms of recovery. Thus, our future work will focus on the underlying mechanisms of behavioral recovery in a PD model in the hope that this will lead to improved understanding of brain function and improved treatment for voice and swallowing disorders.
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DOI：
10.1044/jshd.4301.47
发表时间：
1978-01-01
期刊：
JOURNAL OF SPEECH AND HEARING DISORDERS
影响因子：
--
作者：
LOGEMANN, JA;FISHER, HB;BLONSKY, ER
通讯作者：
BLONSKY, ER
影响因子：
3.6
作者：
Mabandla, M;Kellaway, L;Russell, VA
通讯作者：
Russell, VA
影响因子：
2.8
作者：
Ho, AK;Iansek, R;Gates, S
通讯作者：
Gates, S
影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
影响因子：
9.9
作者：
Liotti, M;Ramig, LO;Fox, PT
通讯作者：
Fox, PT