Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth.
Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth.
复制标题
酵母衍生的纳米粒子重塑肿瘤和肿瘤引流淋巴结中的免疫抑制微环境以抑制肿瘤生长
DOI：
10.1038/s41467-021-27750-2
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发表时间：
2022-01-10
影响因子：
16.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Xu J;Ma Q;Zhang Y;Fei Z;Sun Y;Fan Q;Liu B;Bai J;Yu Y;Chu J;Chen J;Wang C
基于微生物的癌症免疫疗法最近已成为癌症治疗的热门话题。然而，在临床试验中仍存在严重的局限性，包括感染相关的副作用和不满意的结果。在这里，我们制造不同大小的纳米制剂来自酵母细胞壁（YCW纳米颗粒）通过差速离心。由于能够在肿瘤引流淋巴结（TDLN）中积累，我们制剂的抗癌免疫诱导似乎与其大小负相关。此外，我们使用渗流模型来解释它们对TDLN的分布行为。在小尺寸YCW NPs处理后，不仅在肿瘤的微环境中，而且在TDLN中，每个效应成分的丰度和功能取向都得到显著改善。结合程序性死亡配体1（PD-L1）阻断，我们证明了在黑色素瘤攻击小鼠的抗癌效率。我们描绘了通过基于微生物的纳米颗粒靶向免疫抑制微环境的潜在策略，并强调了尺寸效应在基于微生物的免疫治疗中的作用。
Microbe-based cancer immunotherapy has recently emerged as a hot topic for cancer treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction of anticancer immunity of our formulations appears to inversely correlate with their size due to the ability to accumulate in tumor-draining lymph node (TDLN). Moreover, we use a percolation model to explain their distribution behavior toward TDLN. The abundance and functional orientation of each effector component are significantly improved not only in the microenvironment in tumor but also in the TDLN following small size YCW NPs treatment. In combination with programmed death-ligand 1 (PD-L1) blockade, we demonstrate anticancer efficiency in melanoma-challenged mice. We delineate potential strategy to target immunosuppressive microenvironment by microbe-based nanoparticles and highlight the role of size effect in microbe-based immune therapeutics.
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影响因子：
64.5
作者：
Kalafati L;Kourtzelis I;Schulte-Schrepping J;Li X;Hatzioannou A;Grinenko T;Hagag E;Sinha A;Has C;Dietz S;de Jesus Domingues AM;Nati M;Sormendi S;Neuwirth A;Chatzigeorgiou A;Ziogas A;Lesche M;Dahl A;Henry I;Subramanian P;Wielockx B;Murray P;Mirtschink P;Chung KJ;Schultze JL;Netea MG;Hajishengallis G;Verginis P;Mitroulis I;Chavakis T
通讯作者：
Chavakis T
影响因子：
64.5
作者：
Gujar, Shashi;Bell, John;Diallo, Jean-Simon
通讯作者：
Diallo, Jean-Simon
基于可植入血凝块的免疫生态位，用于增强癌症疫苗接种
影响因子：
13.6
作者：
Fan Q;Ma Q;Bai J;Xu J;Fei Z;Dong Z;Maruyama A;Leong KW;Liu Z;Wang C
通讯作者：
Wang C
纳米颗粒与树突状细胞之间的相互作用：从癌症免疫治疗的角度
影响因子：
4.7
作者：
Jia J;Zhang Y;Xin Y;Jiang C;Yan B;Zhai S
通讯作者：
Zhai S
DOI：
10.1038/s41577-019-0269-6
发表时间：
2020-05
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Irvine DJ;Dane EL
通讯作者：
Dane EL