Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects
Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects
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头戴式设备不同光入射角度对健康年轻受试者夜间褪黑激素抑制程度的影响
DOI：
10.1007/s41105-021-00360-7
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发表时间：
2022
影响因子：
1.1
通讯作者：
Yamanaka Yujiro
中科院分区：
文献类型：
--
作者：
Kubota Naoko;Tamori Yusuke;Baba Kenkichi;Yamanaka Yujiro
强光是人类中央昼夜节律起搏器的主要调整器(同步器)。最近，用于光疗的头盔设备已经被开发出来，用于治疗患有昼夜节律睡眠障碍的患者。在这项研究中，为了评估头盔设备的光入射角对人体昼夜节律起搏器的影响，我们从两个不同的角度(55°和28°)检测了强光(约10000×lx)对夜间褪黑素分泌的抑制作用。2 9例受试者(2 5.1 ± 6.3年SD)参与本研究。受试者从习惯就寝前4小时开始保持在暗光条件下(<； 5×lx)，然后在习惯性就寝时间内从两个不同角度暴露在1小时的强光下。在弱光条件下每小时采集一次唾液样本，然后在强光暴露期间每30分钟采集一次。为了评估光入射角对ipRGCs介导光诱发的瞳孔收缩的影响，测量了强光照射前后的瞳孔大小。28°光照组褪黑素抑制率显著高于55°光照组(p<； 0.001)。28°光照组的瞳孔收缩明显大于55°光照组(p<； 0.001)。本研究结果提示，光入射角是强光治疗的一个重要因素，应考虑在家庭和临床环境中有效地使用头盔设备。
Bright light is a primary zeitgeber (synchronizer) for the central circadian pacemaker in humans. Recently, head-mounted devices for light therapy have been developed to treat patients suffering from circadian rhythm sleep disorders. In this study, to evaluate the influence of the light incident angle of head-mounted devices on the human circadian pacemaker, we examined the effects of bright light (ca.10000 lx) from two different angles (55° vs. 28°) on the suppression of melatonin secretion at night. Twenty-nine subjects (25.1 ± 6.3 SD years) participated in the present study. The subjects were kept under dim light conditions (< 5 lx) from 4 h before their habitual bedtime, followed by exposure to 1 h of bright light at two different angles during their habitual bedtime. Saliva samples were collected every hour under dim light conditions and then collected every 30 min during the bright light exposure. To assess the effect of the light incident angle on ipRGCs mediating light-evoked pupillary constriction, pupil size was measured in before and after exposure to bright light. Melatonin suppression in the group exposed to light at 28° was significantly higher than that in the group with light at 55° (p< 0.001). The pupillary constriction was significantly greater in the group exposed to light at 28° than that in the group with light at 55° (p< 0.001). The present findings suggest that the light incident angle is an important factor for bright light therapy and should be considered to effectively use head-mounted devices in home and clinical settings.
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光、眼睛和视觉
DOI：
--
发表时间：
2016
期刊：
影响因子：
--
作者：
I. Herman
通讯作者：
I. Herman
强光疗法：季节性情感障碍及其他。
DOI：
--
发表时间：
2017
期刊：
The Einstein journal of biology and medicine : EJBM
影响因子：
--
作者：
Campbell,PhilipD;Miller,AnnM;Woesner,MaryE
通讯作者：
Woesner,MaryE
影响因子：
3.4
作者：
Mure LS
通讯作者：
Mure LS
DOI：
10.1007/bf02143589
发表时间：
1987
期刊：
Experientia
影响因子：
--
作者：
K. Honma;S. Honma;T. Wada
通讯作者：
T. Wada
影响因子：
2.8
作者：
Wright, HR;Lack, LC
通讯作者：
Lack, LC