Impacts of Environmental Pollution on Brain Tumorigenesis.
Impacts of Environmental Pollution on Brain Tumorigenesis.
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DOI：
10.3390/ijms24055045
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发表时间：
2023-03-06
影响因子：
5.6
通讯作者：
Laezza, Chiara
中科院分区：
文献类型：
--
作者：
Pagano, Cristina;Navarra, Giovanna;Coppola, Laura;Savarese, Beatrice;Avilia, Giorgio;Giarra, Antonella;Pagano, Giovanni;Marano, Alessandra;Trifuoggi, Marco;Bifulco, Maurizio;Laezza, Chiara
污染物由几种成分组成，称为直接或间接诱变剂，可能与肿瘤发生的风险有关。在工业化国家，脑瘤的发病率越来越高，这引起了人们对检查食物、空气或供水中可能存在的不同污染物的更深兴趣。这些化合物，由于其化学性质，改变了体内自然发现的生物分子的活性。生物累积对人类造成有害影响，增加了包括癌症在内的几种疾病的发病风险。环境因素通常与其他风险因素（如个体遗传因素）联合收割机结合，从而增加患癌症的机会。这篇综述的目的是讨论环境致癌物对调节脑肿瘤发生风险的影响，将我们的注意力集中在某些类别的污染物及其来源。
Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.
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影响因子：
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作者：
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