Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rats.
Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rats.
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通过共移植神经和血管祖细胞的神经血管恢复可以改善大鼠缺血性中风后的功能恢复。
DOI：
10.1016/j.stemcr.2014.05.012
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发表时间：
2014-07-08
影响因子：
5.9
通讯作者：
Gao, Wei-Qiang
中科院分区：
文献类型：
--
作者：
Li, Jia;Tang, Yaohui;Wang, Yongting;Tang, Rongbiao;Jiang, Weifang;Yang, Guo-Yuan;Gao, Wei-Qiang
“神经血管单位”的概念强调了脑中神经和血管成分之间的相互作用，提出了旨在神经修复的神经祖细胞（NPC）移植治疗可能不足以治疗缺血性卒中的概念。在这里，我们证明了通过在大鼠中风模型中共移植NPC和胚胎干细胞衍生的血管祖细胞（VPC）来增强神经血管恢复与改善中风后的功能恢复相关。我们发现，共移植促进了来自共移植祖细胞的神经元和血管细胞的存活、迁移、分化和成熟。此外，它引发了来自移植NPC的表达VEGF、BDNF和IGF 1的神经细胞的产生增加。结论：与单纯移植相比，联合移植能更有效地改善神经行为障碍，缩小梗死体积。因此，与单独移植NPC相比，NPC和VPC的联合移植代表了治疗卒中的更有效的治疗策略。缺血性中风的神经和血管祖细胞共移植治疗通过在梗死区域共移植祖细胞实现更好的神经血管恢复通过共移植实现更好的梗死减少和功能恢复可能由生长/营养因子的神经产生介导的神经血管恢复Gao，Yang，和同事证明了神经祖细胞（NPC）共同移植后更有利的神经血管恢复和功能恢复和胚胎干细胞衍生的血管祖细胞比在大鼠中风模型中单独移植NPCs后更显著。共移植不仅能增强移植祖细胞的存活和分化，而且可能通过增加VEGF、BDNF和IGF 1的神经产生来保护宿主脑免于进一步退化。
The concept of the “neurovascular unit,” emphasizing the interactions between neural and vascular components in the brain, raised the notion that neural progenitor cell (NPC) transplantation therapy aimed at neural repair may be insufficient for the treatment of ischemic stroke. Here, we demonstrate that enhanced neurovascular recovery via cotransplantation of NPCs and embryonic stem cell-derived vascular progenitor cells (VPCs) in a rat stroke model is correlated with improved functional recovery after stroke. We found that cotransplantation promoted the survival, migration, differentiation, and maturation of neuronal and vascular cells derived from the cotransplanted progenitors. Furthermore, it triggered an increased generation of VEGF-, BDNF-, and IGF1-expressing neural cells derived from the grafted NPCs. Consistently, compared with transplantation of NPCs alone, cotransplantation more effectively improved the neurobehavioral deficits and attenuated the infarct volume. Thus, cotransplantation of NPCs and VPCs represents a more effective therapeutic strategy for the treatment of stroke than transplantation of NPCs alone. Neural and vascular progenitor cell cotransplantation therapy for ischemic stroke Better neurovascular recovery by cotransplanted progenitor cells in the infarct area Better infarction reduction and functional restoration by cotransplantation Neurovascular recovery likely mediated by neural production of growth/trophic factors Gao, Yang, and colleagues demonstrate a more favorable neurovascular recovery and functional restoration after cotransplantation of neural progenitor cells (NPCs) and embryonic stem cell-derived vascular progenitor cells than after transplantation of NPCs alone in a rat stroke model. Cotransplantation not only reciprocally enhances the survival and differentiation of the transplanted progenitors but also preserves the host brain from further degeneration, likely by increasing neural production of VEGF, BDNF, and IGF1.
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影响因子：
4.2
作者：
HAMM, RJ;PIKE, BR;JENKINS, LW
通讯作者：
JENKINS, LW
影响因子：
4
作者：
Li, Jia;Stuhlmann, Heidi
通讯作者：
Stuhlmann, Heidi
影响因子：
2.7
作者：
Reynolds, BA;Weiss, S
通讯作者：
Weiss, S
影响因子：
8.3
作者：
YANG, GY;BETZ, AL
通讯作者：
BETZ, AL
缺血性中风的细胞疗法：从基础科学到临床。
影响因子：
6.7
作者：
Liu, Xinfeng;Ye, Ruidong;Yan, Tao;Yu, Shan Ping;Wei, Ling;Xu, Gelin;Fan, Xinying;Jiang, Yongjun;Stetler, R. Anne;Liu, George;Chen, Jieli
通讯作者：
Chen, Jieli