Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium.
Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium.
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DOI：
10.2337/dc10-1414
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发表时间：
2011-03
期刊：
影响因子：
16.2
通讯作者：
European Depression in Diabetes Research Consortium
中科院分区：
文献类型：
--
作者：
Nouwen A;Nefs G;Caramlau I;Connock M;Winkley K;Lloyd CE;Peyrot M;Pouwer F;European Depression in Diabetes Research Consortium
荟萃分析显示，2型糖尿病患者患抑郁症的风险升高。对于糖代谢受损（IGM）或未确诊糖尿病（UDD）患者的这种风险相对于正常糖代谢（NGM）升高还是相对于先前诊断的2型糖尿病（PDD）降低，尚未进行系统性综述/荟萃分析。本研究通过回顾文献并对有关这一主题的研究进行荟萃分析，检查了IGM和UDD受试者之间以及与NGM和PDD受试者之间的抑郁症患病率。检索EMBASE和MEDLINE数据库中截至2010年5月发表的文章。所有比较IGM和UDD受试者抑郁症患病率的研究均纳入本研究。使用固定和随机效应模型计算比值比（OR）。荟萃分析显示，IGM与NGM受试者相比，抑郁风险未增加（OR 0.96，95%CI 0.85-1.08）。UDD患者与NGM（OR 0.94，95%CI 0.71-1.25）或IGM（OR 1.16，95%CI 0.88-1.54）患者之间的抑郁风险无差异。最后，IGM或UDD患者患抑郁症的风险均显著低于PDD患者（OR分别为0.59，95%CI 0.48-0.73和0.57，95%CI 0.45-0.74）。这项荟萃分析的结果显示，NGM、IGM和UDD受试者的抑郁风险相似。PDD受试者相对于IGM和UDD受试者具有增加的抑郁风险。
Meta-analyses have shown that the risk for depression is elevated in type 2 diabetes. Whether this risk in individuals with impaired glucose metabolism (IGM) or undiagnosed diabetes (UDD) is elevated relative to normal glucose metabolism (NGM) or decreased relative to previously diagnosed type 2 diabetes (PDD) has not been the subject of a systematic review/meta-analysis. This study examined the prevalence of depression in IGM and UDD subjects relative to each other and to NGM and PDD subjects by reviewing the literature and conducting a meta-analysis of studies on this topic. EMBASE and MEDLINE databases were searched for articles published up to May 2010. All studies that compared the prevalence of depression in subjects with IGM and UDD were included. Odds ratios (ORs) were calculated using fixed and random-effects models. The meta-analysis showed that the risk for depression was not increased in IGM versus NGM subjects (OR 0.96, 95% CI 0.85–1.08). Risk for depression did not differ between individuals with UDD and individuals with either NGM (OR 0.94, 95% CI 0.71–1.25) or IGM (OR 1.16, 95% CI 0.88–1.54). Finally, individuals with IGM or UDD both had a significantly lower risk of depression than individuals with PDD (OR 0.59, 95% CI 0.48–0.73, and OR 0.57, 95% CI 0.45–0.74, respectively). Results of this meta-analysis show that the risk of depression is similar for NGM, IGM, and UDD subjects. PDD subjects have an increased risk of depression relative to IGM and UDD subjects.
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影响因子：
16.2
作者：
Kivimäki M;Tabák AG;Lawlor DA;Batty GD;Singh-Manoux A;Jokela M;Virtanen M;Salo P;Oksanen T;Pentti J;Witte DR;Vahtera J
通讯作者：
Vahtera J
影响因子：
8.2
作者：
Nouwen, A.;Winkley, K.;Twisk, J.;Lloyd, C. E.;Peyrot, M.;Ismail, K.;Pouwer, F.
通讯作者：
Pouwer, F.
影响因子：
16.2
作者：
Katon, WJ;Rutter, C;Von Korff, M
通讯作者：
Von Korff, M
影响因子：
3.5
作者：
Icks, A.;Kruse, J.;Moebus, S.
通讯作者：
Moebus, S.
影响因子：
16.2
作者：
Egede, LE;Zheng, D;Simpson, K
通讯作者：
Simpson, K