Low dose MK-801 reduces social investigation in mice.
Low dose MK-801 reduces social investigation in mice.
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DOI：
10.1016/j.pbb.2008.06.002
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发表时间：
2008-10
影响因子：
3.6
通讯作者：
Yu, Lei
中科院分区：
文献类型：
--
作者：
Zou, Hong;Zhang, Chenghao;Xie, Qinglian;Zhang, Manfang;Shi, Junwei;Jin, Meilei;Yu, Lei
为了表征MK-801对小鼠社会行为的影响，我们检查了成年雄性ICR小鼠与伴侣小鼠（幼年雄性）的相互作用。给试验小鼠注射生理盐水或MK-801（0.1 mg/kg），30 min后在5 min期间测试其社会行为。第二次遭遇发生在30分钟后，与熟悉的同伴老鼠（与第一次遭遇相同）或新的老鼠。在生理盐水对照组中，第二次遇到熟悉的同伴小鼠时，社会调查行为（肛门生殖器嗅闻和呆在一起）减少，表明对熟悉的小鼠的习惯化。第二次遇到一个新的同伴小鼠没有表现出习惯的社会调查行为。MK-801预处理减少了第一次接触时的肛门和生殖器嗅闻。在第二次相遇时，这些小鼠表现出对社会调查行为的非歧视性习惯，减少了肛门和生殖器的嗅探，并保持在一起，无论同伴是熟悉的还是新的。这些结果表明，MK-801影响小鼠的探索活动，导致首次与伴侣小鼠相遇期间的社会调查行为减少，以及随后相遇期间对熟悉与新伴侣小鼠的辨别能力降低。
To characterize MK-801’s effect on social behavior in mice, we examined adult male ICR mice for interaction with companion mice (juvenile male). Test mice were injected with either saline or MK-801 (0.1 mg/kg), and were tested 30 min later for their social behavior during a 5-min session. A second encounter took place 30 min later, with either a familiar companion mouse (the same as in the initial encounter) or a novel mouse. In saline controls, second encounter with a familiar companion mouse showed reduced social investigative behaviors (anogenital sniffing and staying together), indicating habituation toward a familiar mouse. Second encounter with a novel companion mouse did not show habituation in social investigative behaviors. Pretreatment with MK-801 reduced anogenital sniffing during the first encounter. At the second encounter, these mice displayed non-discriminative habituation of social investigative behaviors, with reduced anogenital sniffing and staying together, regardless of whether the companion mouse was a familiar or a novel one. These results indicate that MK-801 affected exploratory activities of mice, resulting in both reduced social investigative behaviors during first encounter with a companion mouse, and diminished discriminative capacities for a familiar vs. a novel companion mouse during subsequent encounter.
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影响因子：
2.9
作者：
Matsuoka, T;Sumiyoshi, T;Kurachi, M
通讯作者：
Kurachi, M
DOI：
10.1037/0735-7036.96.6.1000
发表时间：
1982-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
THOR, DH;HOLLOWAY, WR
通讯作者：
HOLLOWAY, WR
影响因子：
3.4
作者：
Wu, JH;Zou, H;Yu, L
通讯作者：
Yu, L
影响因子：
3.5
作者：
Edsbagge, J;Zhu, SW;Semb, H
通讯作者：
Semb, H
影响因子：
2.1
作者：
Hlinák, Z;Krejcí, I
通讯作者：
Krejcí, I