Central nucleus of the amygdala is involved in induction of yawning response in rats
Central nucleus of the amygdala is involved in induction of yawning response in rats
复制标题
杏仁核中央核参与大鼠打哈欠反应的诱导
DOI：
10.1016/j.bbr.2019.111974
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ichiro Kita
中科院分区：
文献类型：
--
作者：
Natsuko Kubota;Seiichiro Amemiya;Shinya Yanagita;Takeshi Nishijima;Ichiro Kita
打哈欠行为的特征是伴随着深深的吸气而张开嘴巴，以及唤醒反应，并且通常不仅在无聊或困倦的状态下观察到，而且在人类和动物的紧张情绪情况下也观察到。这些现象表明，打哈欠反应可能是一种情绪行为，可能通过激活杏仁核中央核（CeA），这是一个关键的区域的情绪反应。然而，CeA在引发打哈欠中的参与仍然未知。在这里，我们研究是否通过微量注射L-谷氨酸到CeA的CeA的神经元激活能够诱导刻板的打哈欠反应在麻醉，自主呼吸大鼠。此外，我们评估了CeA刺激对下丘脑室旁核（PVN）催产素（OT）和促肾上腺皮质激素释放因子（CRF）神经元激活的影响，室旁核负责诱导打哈欠，使用c-Fos免疫组化。将L-谷氨酸微量注射到CeA中引起血压的初始降压反应和皮层电图上的唤醒移位，随后是单次吸气，这与由PVN刺激引起的刻板哈欠反应的典型模式相同。此外，CeA刺激激活PVN中OT和CRF神经元的神经元活动，以及打哈欠反应。这些结果表明，CeA的激活参与了打哈欠反应的诱导，提示打哈欠是一种情绪行为。
Yawning behavior is characterized by mouth opening accompanied by deep inspiration, as well as arousal response, and is often observed not only in states of boredom or drowsiness, but also in stressful emotional situations in humans and animals. These phenomena suggest that yawning response may be an emotional behavior, possibly through activation of the central nucleus of amygdala (CeA), which is a critical region for emotional responses. However, the involvement of the CeA in triggering yawning remains unknown. Here, we investigated whether neuronal activation of the CeA by microinjection of L-glutamate into the CeA is able to induce stereotyped yawning responses in anesthetized, spontaneously breathing rats. In addition, we assessed the effects of the CeA stimulation on the activation of oxytocin (OT) and CRF (corticotropin-releasing factor) neurons in the paraventricular nucleus of the hypothalamus (PVN), which is responsible for induction of yawning, using c-Fos immunohistochemistry. Microinjection of L-glutamate into the CeA causes an initial depressor response in the blood pressure and an arousal shift on the electrocorticogram followed by a single inspiration, which is the same as the typical pattern of the stereotyped yawning response induced by the PVN stimulation. In addition, the CeA stimulation activated the neuronal activities of both OT and CRF neurons in the PVN, as well as yawning responses. These results indicate that activation of the CeA is involved in the induction of yawning response, suggesting that yawning is an emotional behavior.
登录
查看更多内容
影响因子：
2.9
作者：
Kita, I;Yoshida, Y;Nishino, S
通讯作者：
Nishino, S
阿朴吗啡引起的阴茎勃起和打哈欠：大脑中的作用部位
影响因子：
2.9
作者：
M. R. Melis;A. Argiolas;G. Gessa
通讯作者：
G. Gessa
大鼠室旁核的电和化学刺激引起的刻板打哈欠反应。
影响因子：
2.5
作者：
I. Sato;Ichiro Kita;M. Oguri;H. Arita
通讯作者：
H. Arita
大鼠室旁核局部缺氧引起的打哈欠反应
影响因子：
2.7
作者：
I. Kita;I. Sato;M. Oguri;H. Arita
通讯作者：
H. Arita
将催产素注射到海马腹侧下托，通过增加腹侧被盖区的谷氨酸能神经传递来诱导雄性大鼠阴茎勃起
影响因子：
4.7
作者：
S. Succu;F. Sanna;A. Argiolas;M. R. Melis
通讯作者：
M. R. Melis