Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms
Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms
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睡眠磨牙症受外周苯二氮卓受体基因多态性影响
DOI：
10.1007/s12548-013-0101-z
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ryuji Hosokawa
中科院分区：
文献类型：
--
作者：
Takaya Murakami;Chihiro Masaski;Hidetaka Takahashi;Michiko Makino;Taro Mukaibo;Yusuke Kondo;Tetsuji Nakamoto;Ryuji Hosokawa
背景越来越多的人对睡眠磨牙症的遗传效应以及心理压力感兴趣。外周型苯二氮卓类受体(PBR)基因多态性与应激敏感性有关，但目前尚不清楚该基因多态性是否对睡眠磨牙症前后的心理应激有影响。本研究旨在探讨睡眠磨牙症与PBR基因多态性的关系。材料与方法研究对象包括30名男性和28名女性健康志愿者，平均年龄24.0岁。采集口腔黏膜细胞DNA，用phi29DNA聚合酶扩增PBR基因。聚合酶链式反应扩增PBR基因后，直接测序鉴定基因的多态性。睡眠时也使用便携式肌电图仪测量咬肌活动，以评估睡眠磨牙症。结果G/G基因携带者32例(68.1 %)，G/A基因携带者13例(27.6 %)，A/A基因携带者2例(27.6%)。G/A组磨牙症发生率明显高于G/G组(P<； 0.05)。G/A组唾液CgA水平变化明显低于G/G组(P<； 0.0 5)。结论PBR基因多态性等遗传因素可能通过磨牙症影响心理应激管理。在治疗睡眠磨牙症时，重要的是要考虑到遗传因素，采用个性化的药物治疗方法。
BackgroundThere is increasing interest in genetic effects on sleep bruxism, as well as on psychological stress. Peripheral type benzodiazepine receptor (PBR) gene polymorphisms are associated with stress sensitivity but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress before and after sleep bruxism. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphisms.Materials and methodsThe study population consisted of 30 male and 28 female healthy volunteers with a mean age of 24.0 years. The PBR gene was amplified using phi29 DNA polymerase after collection of DNA from oral mucosa cells. Polymorphisms were identified by direct sequencing after PBR gene amplification by PCR. Masseter muscle activity was also measured during sleep using portable electromyography to evaluate sleep bruxism. Furthermore, stimulated whole saliva samples were collected for quantification of the salivary chromogranin A (CgA) level as an index of psychological stress.ResultsThe results show that 32 subjects (68.1 %) had the G/G genotype, 13 (27.6 %) had G/A and 2 had A/A. The number of bruxism events was significantly higher in the G/A group than in the G/G group (P< 0.05). Changes in salivary CgA levels were significantly lower in the G/A group than in the G/G group (P< 0.05).ConclusionsGenetic factors, such as PBR gene polymorphisms, may influence psychological stress management through bruxism during sleep. When treating sleep bruxism it is important to take genetic factors into consideration for a personalized medicine approach.
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