Dietary correlates of urinary phthalate metabolite concentrations in 6-19 Year old children and adolescents.
Dietary correlates of urinary phthalate metabolite concentrations in 6-19 Year old children and adolescents.
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DOI：
10.1016/j.envres.2021.112083
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发表时间：
2022-03
影响因子：
8.3
通讯作者：
Fleisch AF
中科院分区：
文献类型：
--
作者：
Carwile JL;Seshasayee SM;Ahrens KA;Hauser R;Chavarro JE;Fleisch AF
儿童很容易受到与邻苯二甲酸盐相关的不良健康影响，而食物是接触源之一。尚未对尿液中邻苯二甲酸酯代谢物浓度与食物类型和来源的关系进行全面分析。在美国的一项大型研究中，我们使用降序回归（一种降维方法）来确定与儿童尿邻苯二甲酸盐代谢物相关的饮食模式。我们使用了 2011 年至 2016 年国家健康与营养检查调查中 2,369 名 6-19 岁参与者的数据，他们回忆了尿液收集前 24 小时内的饮食情况。我们使用饮食数据来估计 136 种食物的摄入量和来源（即在餐馆准备的与从杂货店购买的）。我们使用降序回归来确定饮食模式，解释邻苯二甲酸二-2-乙基己酯和七种邻苯二甲酸酯代谢物的总体尿液浓度的变化。我们还研究了食物组和尿邻苯二甲酸酯代谢物之间的成对关联。我们确定了八种饮食模式，累计解释了尿邻苯二甲酸酯代谢物变异的 12.1%，其中包括以某些淀粉类蔬菜（例如车前草和利马豆）、速食面包和餐厅准备的柑橘汁为特征的饮食模式。该食物模式评分每增加一个标准差，邻苯二甲酸单羧辛酯 (MCOP) 浓度就会增加 37.2%（95% CI：30.3、44.4）。我们还观察到某些食物组与尿邻苯二甲酸酯代谢物之间存在微弱关联（例如，餐厅准备的某些淀粉类蔬菜的摄入量增加 1 个标准差与 MCOP 升高 1.8% [95% CI: 0.7, 2.8] 相关）。饮食以摄入较多某些淀粉类蔬菜、速食面包和餐厅准备的柑橘汁为特征的儿童，尿中邻苯二甲酸盐代谢物含量较高。需要有关食品加工具体方法和包装材料细节的更多详细信息。
Children are vulnerable to adverse health effects associated with phthalates, and food is one source of exposure. A comprehensive analysis investigating urinary phthalate metabolite concentrations in relation to food type and source has yet to be undertaken. We use reduced rank regression, a dimension reduction method, to identify dietary patterns associated with urinary phthalate metabolites in children in a large US study. We used data from 2,369 participants 6–19 years old from the 2011—2016 National Health and Nutrition Examination Survey who recalled their diet over the 24 hours prior to urine collection. We used dietary data to estimate intake and source (i.e., prepared at a restaurant vs. purchased from a grocery store) of 136 food groups. We used reduced rank regression to identify dietary patterns explaining variation in overall urinary concentrations of ∑di-2-ethylhexyl phthalate and seven phthalate metabolites. We also examined pairwise associations between food groups and urinary phthalate metabolites. We identified eight dietary patterns that cumulatively explained 12.1% of variation in urinary phthalate metabolites, including a dietary pattern characterized by certain starchy vegetables (e.g., plantains and lima beans), quick breads, and citrus juice prepared at a restaurant. A one SD increase in this food pattern score was associated with a 37.2% higher monocarboxyoctyl phthalate (MCOP) concentration (95% CI: 30.3, 44.4). We also observed weak associations between certain food groups and urinary phthalate metabolites (e.g., a one SD increase in intake of certain starchy vegetables prepared at a restaurant was associated with a 1.8% [95% CI: 0.7, 2.8] higher MCOP). Children whose diets were characterized by higher consumption of certain starchy vegetables, quick breads, and citrus juices prepared at a restaurant had higher urinary phthalate metabolites. More detailed information on the specific methods of food processing and details on packaging materials is needed.
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影响因子：
10.4
作者：
Schecter A;Lorber M;Guo Y;Wu Q;Yun SH;Kannan K;Hommel M;Imran N;Hynan LS;Cheng D;Colacino JA;Birnbaum LS
通讯作者：
Birnbaum LS
影响因子：
5
作者：
Hoffmann, K;Schulze, MB;Boeing, H
通讯作者：
Boeing, H
影响因子：
10.4
作者：
Colacino JA;Harris TR;Schecter A
通讯作者：
Schecter A
影响因子：
11.8
作者：
Johns LE;Cooper GS;Galizia A;Meeker JD
通讯作者：
Meeker JD
DOI：
10.1186/s12940-017-0310-9
发表时间：
2017-09-26
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Park SK;Zhao Z;Mukherjee B
通讯作者：
Mukherjee B