Dietary intake is associated with phthalate body burden in a nationally representative sample.
Dietary intake is associated with phthalate body burden in a nationally representative sample.
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DOI：
10.1289/ehp.0901712
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发表时间：
2010-07
影响因子：
10.4
通讯作者：
Schecter A
中科院分区：
文献类型：
--
作者：
Colacino JA;Harris TR;Schecter A
邻苯二甲酸盐是广泛用于消费品的化合物。然而，膳食摄入量对邻苯二甲酸盐暴露的影响尚未明确。本研究的目的是评估不同食物类型对邻苯二甲酸盐暴露的影响。邻苯二甲酸盐是令人关注的化学物质，因为在人和环境中测得的邻苯二甲酸盐含量很高，而且在动物研究和有限的流行病学研究中已证明具有毒性。先前的研究虽然有限，但表明邻苯二甲酸盐污染了多个国家的食品。我们对 2003-2004 年国家健康和营养检查调查 (NHANES) 收集的数据进行了探索性分析。使用多元线性回归模型分析了一系列食物类型（肉类、家禽、鱼类、水果、蔬菜和乳制品）的饮食摄入量（通过 24 小时饮食回忆进行评估）与尿液中测得的邻苯二甲酸盐代谢物之间的关联。我们发现邻苯二甲酸二（2-乙基己基）酯（DEHP）的代谢物和高分子量邻苯二甲酸酯代谢物与家禽的消耗有关。邻苯二甲酸单乙酯是邻苯二甲酸二乙酯 (DEP) 的代谢产物，与蔬菜消费有关，特别是番茄和马铃薯的消费。这些结果与之前的研究结果相结合，表明饮食是邻苯二甲酸盐的重要摄入途径。需要进一步研究来确定这些有毒化学物质的食品污染源，并描述美国大型代表性样本中美国食品的污染水平。
Phthalates are compounds that are used in a wide range of consumer products. However, the contribution of dietary intake to phthalate exposure has not been well defined. The objective of this study was to assess the contribution of different food types to phthalate exposure. Phthalates are chemicals of concern because of the high levels measured in people and the environment, as well as the demonstrated toxicity in animal studies and limited epidemiological studies. Previous research, although limited, has suggested that phthalates contaminate food in various countries. We conducted an exploratory analysis of data collected as part of the 2003–2004 National Health and Nutrition Examination Survey (NHANES). Associations between dietary intake (assessed by a 24-hr dietary recall) for a range of food types (meat, poultry, fish, fruit, vegetable, and dairy) and phthalate metabolites measured in urine were analyzed using multiple linear regression modeling. We found that metabolites of di-(2-ethylhexyl) phthalate (DEHP) and high-molecular-weight phthalate metabolites were associated with the consumption of poultry. Monoethyl phthalate, the metabolite of diethyl phthalate (DEP), was associated with vegetable consumption, specifically tomato and potato consumption. These results, combined with results from previous studies, suggest that diet is an important route of intake for phthalates. Further research is needed to determine the sources of food contamination with these toxic chemicals and to describe the levels of contamination of U.S. food in a large, representative U.S. sample.
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影响因子：
--
作者：
Meeker JD;Calafat AM;Hauser R
通讯作者：
Hauser R
影响因子：
10.4
作者：
Schecter A;Haffner D;Colacino J;Patel K;Päpke O;Opel M;Birnbaum L
通讯作者：
Birnbaum L
影响因子：
7.4
作者：
Kato, K;Silva, MJ;Calafat, AM
通讯作者：
Calafat, AM
影响因子：
8.3
作者：
Sathyanarayana, S.;Calafat, A. M.;Swan, S. H.
通讯作者：
Swan, S. H.
女性生殖系统中邻苯二甲酸酯毒性的机制。
影响因子：
10.4
作者：
Lovekamp-Swan, T;Davis, BJ
通讯作者：
Davis, BJ