Intestinal epithelial cells as mediators of the commensal-host immune crosstalk.
Intestinal epithelial cells as mediators of the commensal-host immune crosstalk.
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DOI：
10.1038/icb.2012.80
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发表时间：
2013-03
影响因子：
4
通讯作者：
Ivanov, Ivaylo I.
中科院分区：
文献类型：
--
作者：
Goto, Yoshiyuki;Ivanov, Ivaylo I.
共生细菌调节宿主效应免疫细胞亚群的动态平衡。这种共生-宿主串扰涉及的机制还不是很清楚。肠上皮细胞(IECS)不仅在宿主组织中的共生体和免疫细胞之间建立物理屏障，而且促进它们之间的相互作用。上皮细胞动态平衡或功能的紊乱会导致肠道疾病的发展，如炎症性肠病(IBD)和肠癌。IEC接收来自共生体的信号，并产生效应器免疫分子。IECS还影响固有层免疫细胞的功能。在这里，我们讨论IECs的一些属性，这些属性将它们定义为先天免疫细胞。我们关注IECS如何整合并将信号从单个共生细菌传递到粘膜固有免疫细胞和获得性免疫细胞，以建立独特的粘膜免疫平衡。
Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal–host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial homeostasis or function lead to the development of intestinal disorders such as inflammatory bowel diseases (IBD) and intestinal cancer. IECs receive signals from commensals and produce effector immune molecules. IECs also affect the function of immune cells in the lamina propria. Here we discuss some of these properties of IECs that define them as innate immune cells. We focus on how IECs may integrate and transmit signals from individual commensal bacteria to mucosal innate and adaptive immune cells for the establishment of the unique mucosal immunological equilibrium.
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影响因子：
64.8
作者：
CEPEK, KL;SHAW, SK;BRENNER, MB
通讯作者：
BRENNER, MB
影响因子：
6.4
作者：
Heczko, U;Abe, A;Finlay, BB
通讯作者：
Finlay, BB
DOI：
10.1084/jem.172.1.239
发表时间：
1990-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bandeira A;Mota-Santos T;Itohara S;Degermann S;Heusser C;Tonegawa S;Coutinho A
通讯作者：
Coutinho A
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi