Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables.
Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables.
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DOI：
10.1289/ehp.1104802
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发表时间：
2012-07
影响因子：
10.4
通讯作者：
Webster TF
中科院分区：
文献类型：
--
作者：
Stapleton HM;Eagle S;Sjödin A;Webster TF
背景：多溴二苯醚 (PBDE) 是一种持久性、生物累积性和内分泌干扰性化学物质。目的：我们使用手巾来估计幼儿在室内灰尘中的 PBDE 暴露量，并检查性别、年龄、母乳喂养、种族和父母教育程度作为血清 PBDE 的预测因素。方法：2009 年 5 月至 2010 年 11 月期间，在北卡罗来纳州招募了 83 名 12 至 36 个月大的儿童。收集了血液、手巾和室内灰尘样本并分析了 PBDE。进行问卷调查以收集人口统计数据。结果：所有血清样品、98% 的手巾样品和 100% 的灰尘样品中均检测到了 PBDE（血清中 ΣpentaBDE 的几何平均值为 43.3 ng/g 脂质）。血清 ΣpentaBDE 与手巾和室内灰尘 ΣpentaBDE 水平显着相关，但与手巾水平的相关性更强（r = 0.57；p < 0.001 vs. r = 0.35；p < 0.01）。多变量模型估计显示，手擦水平、儿童性别、儿童年龄和父亲的教育程度占血清 ΣBDE3 水平（BDE 47、99 和 100 之和）变异的 39%。相比之下，年龄、手巾水平和母乳喂养时间可以解释 39% 的血清 BDE 153 变异。 结论：我们的研究表明，手-口活动可能是接触 PBDE 的一个重要来源。此外，年龄、社会经济地位和母乳喂养是暴露的重要预测因素，但相关性因同类而异。具体而言，血清ΣBDE3与社会经济地位呈负相关，而血清BDE-153与母乳喂养时间和母亲受教育程度呈正相关。
Background: Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. Objectives: We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents’ education as predictors of serum PBDEs. Methods: Eighty-three children from 12 to 36 months of age were enrolled in North Carolina between May 2009 and November 2010. Blood, handwipe, and house dust samples were collected and analyzed for PBDEs. A questionnaire was administered to collect demographic data. Results: PBDEs were detected in all serum samples (geometric mean for ΣpentaBDE in serum was 43.3 ng/g lipid), 98% of the handwipe samples, and 100% of the dust samples. Serum ΣpentaBDEs were significantly correlated with both handwipe and house dust ΣpentaBDE levels, but were more strongly associated with handwipe levels (r = 0.57; p < 0.001 vs. r = 0.35; p < 0.01). Multivariate model estimates revealed that handwipe levels, child’s sex, child’s age, and father’s education accounted for 39% of the variation in serum ΣBDE3 levels (sum of BDEs 47, 99, and 100). In contrast, age, handwipe levels, and breast-feeding duration explained 39% of the variation in serum BDE 153. Conclusions: Our study suggests that hand-to-mouth activity may be a significant source of exposure to PBDEs. Furthermore, age, socioeconomic status, and breast-feeding were significant predictors of exposure, but associations varied by congener. Specifically, serum ΣBDE3 was inversely associated with socioeconomic status, whereas serum BDE-153 was positively associated with duration of breast-feeding and mother’s education.
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影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
通讯作者：
Perera F
影响因子：
11.4
作者：
Johnson, Paula I.;Stapleton, Heather M.;Slodin, Andreas;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
8
作者：
Rhoads, GG;Ettinger, AS;Lioy, PJ
通讯作者：
Lioy, PJ
影响因子：
3.8
作者：
Dingemans, Milou M. L.;van den Berg, Martin;Westerink, Remco H. S.
通讯作者：
Westerink, Remco H. S.
影响因子：
11.4
作者：
Rose M;Bennett DH;Bergman A;Fängström B;Pessah IN;Hertz-Picciotto I
通讯作者：
Hertz-Picciotto I