Relationships between polybrominated diphenyl ether concentrations in house dust and serum.
Relationships between polybrominated diphenyl ether concentrations in house dust and serum.
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DOI：
10.1021/es100697q
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发表时间：
2010-07-15
影响因子：
11.4
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Johnson, Paula I.;Stapleton, Heather M.;Slodin, Andreas;Meeker, John D.
在家庭环境和人体中测量了多溴联苯醚，但将环境水平与身体负担联系起来的研究有限。这项研究调查了居住在这些家庭的成年人的房屋灰尘和血清中多溴二苯醚浓度之间的关系。我们测量了50个家庭的室内灰尘和12个家庭的男女夫妇的血清中的多溴二苯醚浓度。检测率、灰尘-血清和基质内相关性因多溴二苯醚同系物而异。灰尘和血清中几种主要多溴二苯醚同系物（BDE 47、BDE 99和BDE 100）的浓度之间存在很强的相关性（r = 0.65-0.89，p < 0.05）。粉尘与血清中BDE 153浓度无相关性（r < 0.01）。由于BDE 209在血清中的检出率较低，因此无法评估灰尘与BDE 209血清浓度之间的相关性。在夫妇之间，BDE 47、BDE 99和BDE 100的血清浓度总和也有很强的相关性（r = 0.85，p = 0.0005）。这项研究提供的证据表明，房屋灰尘是多溴二苯醚的主要接触途径，并支持使用灰尘多溴二苯醚浓度作为接触BDE 153以外的多溴二苯醚同系物的标志。
Polybrominated diphenyl ethers (PBDEs) have been measured in the home environment and in humans, but studies linking environmental levels to body burdens are limited. This study examines the relationship between PBDE concentrations in house dust and serum from adults residing in these homes. We measured PBDE concentrations in house dust from 50 homes and in serum of male-female couples from 12 of the homes. Detection rates, dust-serum and within-matrix correlations varied by PBDE congener. There was a strong correlation (r = 0.65–0.89, p < 0.05) between dust and serum concentrations of several predominant PBDE congeners (BDE 47, 99 and 100). Dust and serum levels of BDE 153 were not correlated (r < 0.01). The correlation of dust and serum levels of BDE 209 could not be evaluated due to low detection rates of BDE 209 in serum. Serum concentrations of the sum of BDE 47, 99, and 100 were also strongly correlated within couples (r = 0.85, p = 0.0005). This study provides evidence that house dust is a primary exposure pathway of PBDEs and supports the use of dust PBDE concentrations as a marker for exposure to PBDE congeners other than BDE 153.
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影响因子：
8.8
作者：
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通讯作者：
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影响因子：
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作者：
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