Vascular endothelial growth factor (VEGF) expression during arterial repair in the pig.
Vascular endothelial growth factor (VEGF) expression during arterial repair in the pig.
复制标题
猪动脉修复过程中血管内皮生长因子（VEGF）的表达。
DOI：
10.1016/s1078-5884(98)80180-9
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Paul Norman
中科院分区：
文献类型：
--
作者：
S. Wysocki;Ming Zheng;Anne Smith;Paul Norman
OBJECTIVESVascular endothelial growth factor (VEGF) is reported to be a potent and specific mitogen for endothelial cells (EC) and an inducer of angiogenesis in vivo. Originally called vascular permeability factor (VPF), VEGF also increases permeability of microvessels to circulating macromolecules. The aim of this study was to examine whether the VEGF gene was expressed in porcine arteries following denudation of EC.DESIGNExperimental animal model with mechanical injury to large arteries.METHODSThe right iliac artery of juvenile pigs was de-endothelialised using an inflated balloon catheter. At a number of time-points after injury, these arteries were harvested together with uninjured contralateral arteries. Sections of arteries were used for RNA analysis by Northern blots and for protein localisation studies by immunohistochemistry.RESULTSTwo VEGF transcripts (2.0 kb, 4.5 kb) were markedly elevated in pig arteries soon after injury. Newly synthesised VEGF protein was located in smooth muscle cells (SMC) throughout the media of injured arteries.CONCLUSIONSThe elevated expression of VEGF by SMC in denuded porcine arteries is evidence that this cytokine plays a role in the injury response of large arteries. Since several biological activities have been identified for VEGF, the function of this cytokine in the arterial repair process remains to be determined.
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影响因子：
3.3
作者：
BERSE, B;BROWN, LF;SENGER, DR
通讯作者：
SENGER, DR
血管重建后狭窄的预防：内膜增生的药物控制——综述。
影响因子：
4.3
作者：
Clowes,AW;Reidy,MA
通讯作者：
Reidy,MA
DOI：
10.1161/01.atv.13.8.1218
发表时间：
1993-08-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
JACKSON, CL;RAINES, EW;REIDY, MA
通讯作者：
REIDY, MA
影响因子：
37.8
作者：
ASAHARA, T;BAUTERS, C;ISNER, JM
通讯作者：
ISNER, JM