Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching.
Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching.
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DOI：
10.1016/j.cell.2013.12.008
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发表时间：
2014-01-16
期刊：
影响因子：
64.5
通讯作者：
Miguel-Aliaga I
中科院分区：
文献类型：
--
作者：
Linneweber GA;Jacobson J;Busch KE;Hudry B;Christov CP;Dormann D;Yuan M;Otani T;Knust E;de Bono M;Miguel-Aliaga I
适应性血管生成是癌症和肥胖病因和治疗的关键过程，在血管生成过程中，血管系统会改变以满足其靶组织的代谢需要。尽管控制血管重构的线索尚未完全了解，但靶标衍生信号通常被认为是这一过程的基础。在这里，我们通过表征果蝇气管系统以前未被认识到的营养依赖性可塑性，确定了另一种机制：一个与哺乳动物血管发育相似的供氧小管网络。我们发现，这种可塑性，尤其是在肠道中，是对代谢变化的驱动，而不是响应。从机制上讲，它是由不同的营养和氧反应神经元群体调节的，这些神经元通过局部和全身胰岛素和vip样神经肽的传递，塑造特定气管亚群的生长。因此，我们描述了一种新的机制，通过营养线索调节神经元活动，从而引起器官特异性的血管结构的长期变化。果蝇气管系统表现出营养依赖的可塑性，气管可塑性是器官特异性的，具有显著的代谢意义。营养和缺氧反应神经元驱动适应性气管。不同的胰岛素样神经肽和Pdf神经肽控制器官特异性气管分支。此前，果蝇气管系统未被认识到的营养依赖可塑性驱动代谢变化，并由不同的营养和氧反应神经元群体调节。
During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture. The Drosophila tracheal system exhibits nutrient-dependent plasticity Tracheal plasticity is organ specific and metabolically significant Nutrient- and hypoxia-responsive neurons drive adaptive tracheation Distinct insulin-like and Pdf neuropeptides control organ-specific tracheal branching Previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system drives metabolic change and is regulated by distinct populations of nutrient- and oxygen-responsive neurons.
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影响因子：
120.1
作者：
Cao, Yihai
通讯作者：
Cao, Yihai
影响因子：
2.8
作者：
Cheung, Una;Moghaddasi, Mehrnoush;Woodin, Melanie A.
通讯作者：
Woodin, Melanie A.
影响因子：
64.5
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
通讯作者：
Hafen, E
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E
影响因子：
11.4
作者：
Leevers, SJ;Weinkove, D;Waterfield, MD
通讯作者：
Waterfield, MD