Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals.
Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals.
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DOI：
10.1371/journal.pone.0012561
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发表时间：
2010-09-03
期刊：
影响因子：
3.7
通讯作者：
Langland JO
中科院分区：
文献类型：
--
作者：
Denzler KL;Waters R;Jacobs BL;Rochon Y;Langland JO
数百种植物药作为抗菌药物和免疫刺激剂用于补充和替代医学的治疗用途。虽然存在许多世纪的轶事证据和关于这些植物的活性和功效的临床研究很少，但关于这些植物调节免疫和炎症反应的能力的科学证据有限。使用植物基因组学（或herbogenomics），这项研究提供了新的见解，炎症基因诱导外周血单核细胞与免疫调节植物提取物治疗后。这些结果可能表明，假定的基因参与的生理反应，认为发生后，这些植物提取物管理。使用免疫刺激草药（黄芪，接骨木，穿心莲）和免疫抑制草药（异株荨麻）的提取物，所提供的数据支持这些草药的细胞因子研究，以及确定可能参与免疫细胞活化和迁移以及各种炎症反应，包括伤口愈合，血管生成和血压调节的其他基因。此外，我们报告了脂多糖在这些草药的药用提取物中的存在，理论上它是免疫刺激草药提取物的天然活性成分。所提供的数据提供了一个更广泛的图片，这些草药可能是如何介导其对免疫和炎症反应的生物学效应。
Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses.
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DOI：
10.1152/ajpendo.00004.2002
发表时间：
2003-10-01
影响因子：
5.1
作者：
Hallemeesch, MM;Janssen, BJA;Deutz, NEP
通讯作者：
Deutz, NEP
影响因子：
2.9
作者：
Block, Keith I;Mead, Mark N
通讯作者：
Mead, Mark N
DOI：
10.1358/mf.2009.31.2.1353846
发表时间：
2009-03-01
影响因子：
--
作者：
Han, D. -O.;Lee, H. -J.;Hahm, D. -H.
通讯作者：
Hahm, D. -H.
影响因子：
1.8
作者：
Chen, W.;Li, Y. -M.;Yu, M. -H.
通讯作者：
Yu, M. -H.
影响因子：
5.8
作者：
Caroff, M;Karibian, D;Haeffner-Cavaillon, N
通讯作者：
Haeffner-Cavaillon, N