Effect of fabrication-dependent shape and composition of solid-state nanopores on single nanoparticle detection.
Effect of fabrication-dependent shape and composition of solid-state nanopores on single nanoparticle detection.
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DOI：
10.1021/nn4020642
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发表时间：
2013-06-25
期刊：
影响因子：
17.1
通讯作者：
Schmidt, Holger
中科院分区：
文献类型：
--
作者：
Liu, Shuo;Yuzvinsky, Thomas D.;Schmidt, Holger
关键词：
固态纳米孔可以以多种方式制造，并形成单个纳米颗粒的无标记传感的基础：当单个纳米颗粒穿过纳米孔时，它们以特征方式改变穿过纳米孔的离子电流。通常，纳米孔通过其极限孔径的直径来描述，并且较少关注其他依赖于制造的参数。在这里，我们报告了三种类型的纳米孔具有相同的50 nm孔径的属性和传感性能的全面分析，但使用三种不同的技术制造：直接离子束铣削，离子束雕刻，和电子束雕刻。纳米孔在物理形状和化学组成上显著不同，如通过离子束辅助横截面和能量色散X射线光谱所鉴定的。使用流体动力学模拟观察并建模单个30 nm珠的电感测中的伴随差异，例如阻断深度、持续时间和电场依赖性的变化。实验和物理建模之间的良好一致性表明，在没有故意表面改性的情况下，物理性质（形状）而不是化学表面组成决定了固态纳米孔的传感性能。因此，一旦已知纳米孔的完整三维结构，就可以准确地预测纳米颗粒感测性能。
Solid-state nanopores can be fabricated in a variety of ways and form the basis for label-free sensing of single nanoparticles: as individual nanoparticles traverse the nanopore, they alter the ionic current across it in a characteristic way. Typically, nanopores are described by the diameter of their limiting aperture, and less attention has been paid to other, fabrication-dependent parameters. Here, we report a comprehensive analysis of the properties and sensing performance of three types of nanopore with identical 50nm aperture, but fabricated using three different techniques: direct ion beam milling, ion beam sculpting, and electron beam sculpting. The nanopores differ substantially in physical shape and chemical composition as identified by ion-beam assisted cross sectioning and energy dispersive x-ray spectroscopy. Concomitant differences in electrical sensing of single 30nm beads, such as variations in blockade depth, duration, and electric field dependence, are observed and modeled using hydrodynamic simulations. The excellent agreement between experiment and physical modeling shows that the physical properties (shape) and not the chemical surface composition determine the sensing performance of a solid-state nanopore in the absence of deliberate surface modification. Consequently, nanoparticle sensing performance can be accurately predicted once the full three dimensional structure of the nanopore is known.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2
作者：
Holmes, Matthew R.;Shang, Tao;Schmidt, Holger
通讯作者：
Schmidt, Holger
影响因子：
7.4
作者：
Lan, Wen-Jie;Holden, Deric A.;White, Henry S.
通讯作者：
White, Henry S.
影响因子：
1.6
作者：
DEBLOIS, RW;BEAN, CP
通讯作者：
BEAN, CP
DOI：
10.1073/pnas.1001831107
发表时间：
2010-09-14
影响因子：
11.1
作者：
Derrington, Ian M.;Butler, Tom Z.;Gundlach, Jens H.
通讯作者：
Gundlach, Jens H.