Differences between normal and diabetic brains in middle-aged rats by MRI.
Differences between normal and diabetic brains in middle-aged rats by MRI.
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DOI：
10.1016/j.brainres.2019.146407
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发表时间：
2019-12-01
期刊：
影响因子：
2.9
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Ding G;Chopp M;Li L;Zhang L;Davoodi-Bojd E;Li Q;Wei M;Zhang Z;Jiang Q
正常衰老是糖尿病等代谢疾病的危险因素，糖尿病也是公认的加速衰老的原因。能够区分正常衰老引起的变化与糖尿病引起的变化，将有助于了解衰老的大脑如何与糖尿病相互作用。对正常青年、健康和1.5个月糖尿病中年大鼠三组的所有大鼠生成八种类型的MRI度量图（T1和T2的磁化弛豫时间常数、脑血流量、脑血管通透性、平均扩散率、扩散分数各向异性、平均扩散峰度和扩散方向熵）。三组动物大脑白色和灰质的多个MRI指标的测量提供了互补的结果，并深入了解中年大鼠健康和糖尿病白色/灰质之间的差异。我们的数据表明，MRI可以区分正常和糖尿病在中年大鼠脑灰质的T1和T2，或分数各向异性的白色物质和灰质。因此，MRI可以区分正常衰老与糖尿病衰老引起的脑组织变化，这可能有助于更好地了解糖尿病如何加速正常大脑的衰老。
Normal aging is a risk factor for metabolic disorders such as diabetes, and diabetes is also a recognized cause of accelerated aging. Being able to distinguish changes caused by normal aging from those caused by diabetes, would provide insight into how the aging brain interacts with diabetes. Eight types of MRI metric maps (magnetization relaxation time constants of T1 and T2, cerebral blood flow, cerebrovascular permeability, mean diffusivity, diffusion fractional anisotropy, mean diffusion kurtosis and diffusion directional entropy) were generated for all rats from the three groups of normal young, healthy and 1.5-month diabetic middle-aged rats under investigation. Measurements of multiple MRI indices of cerebral white and gray matter from animals of the three groups provide complementary results and insight into differences between healthy and diabetic white / gray matter in the mid-aged rats. Our data indicate that MRI may distinguish between the normal and diabetes in mid-aged rat brains by measuring either T1 and T2 of gray matter, or fractional anisotropy of white matter and gray matter. Therefore, MRI can distinguish changes of cerebral tissue due to the normal aging from diabetic aging, which may lead to be able to better understand how diabetes accelerates aging in normal brain.
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