How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between fMRI and behaviour-only research participants.
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between fMRI and behaviour-only research participants.
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DOI：
10.1093/scan/nsab057
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发表时间：
2021-09-30
影响因子：
4.2
通讯作者：
O'Doherty JP
中科院分区：
文献类型：
--
作者：
Charpentier CJ;Faulkner P;Pool ER;Ly V;Tollenaar MS;Kluen LM;Fransen A;Yamamori Y;Lally N;Mkrtchian A;Valton V;Huys QJM;Sarigiannidis I;Morrow KA;Krenz V;Kalbe F;Cremer A;Zerbes G;Kausche FM;Wanke N;Giarrizzo A;Pulcu E;Murphy S;Kaltenboeck A;Browning M;Paul LK;Cools R;Roelofs K;Pessoa L;Harmer CJ;Chase HW;Grillon C;Schwabe L;Roiser JP;Robinson OJ;O'Doherty JP
在过去的三十年里，功能性磁共振成像（fMRI）已成为研究人类大脑中认知过程如何实现的关键。然而，被招募到fMRI研究的参与者是否与被招募到其他研究环境中的参与者不同的问题几乎没有受到关注。这是特别相关的影响时，未能概括整个研究背景：例如，在一个非成像环境中发现的行为效果不复制在神经成像环境。在这里，我们测试的假设，动机的初步研究结果（N = 272），即功能磁共振成像参与者不同于行为只参与者的一个基本的个体差异变量：特质焦虑。通过分析来自多个机构的健康志愿者（N = 3317）的特质焦虑评分和可能的混杂变量，我们发现fMRI研究参与者的特质焦虑较低，这与抽样或自我选择偏差一致。在依赖于电话筛查的研究中（与全面的面对面精神病筛查相比），至少部分从便利样本中招募（与社区样本相比），以及药理学研究中，偏差更大。我们的研究结果强调，需要在招聘和适当的筛选程序或抽样策略，以减轻这种偏见的特质焦虑。
Over the past three decades, functional magnetic resonance imaging (fMRI) has become crucial to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into fMRI studies differ from participants recruited into other study contexts has received little to no attention. This is particularly pertinent when effects fail to generalize across study contexts: for example, a behavioural effect discovered in a non-imaging context not replicating in a neuroimaging environment. Here, we tested the hypothesis, motivated by preliminary findings (N = 272), that fMRI participants differ from behaviour-only participants on one fundamental individual difference variable: trait anxiety. Analysing trait anxiety scores and possible confounding variables from healthy volunteers across multiple institutions (N = 3317), we found robust support for lower trait anxiety in fMRI study participants, consistent with a sampling or self-selection bias. The bias was larger in studies that relied on phone screening (compared with full in-person psychiatric screening), recruited at least partly from convenience samples (compared with community samples), and in pharmacology studies. Our findings highlight the need for surveying trait anxiety at recruitment and for appropriate screening procedures or sampling strategies to mitigate this bias.
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DOI：
10.1073/pnas.1800547115
发表时间：
2018-07-31
影响因子：
11.1
作者：
Charpentier CJ;Bromberg-Martin ES;Sharot T
通讯作者：
Sharot T
影响因子：
10.6
作者：
Charpentier CJ;Aylward J;Roiser JP;Robinson OJ
通讯作者：
Robinson OJ
影响因子：
10.6
作者：
Grillon, C
通讯作者：
Grillon, C
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH
DOI：
10.1176/appi.ajp.2009.09070931
发表时间：
2010-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Etkin A;Prater KE;Hoeft F;Menon V;Schatzberg AF
通讯作者：
Schatzberg AF