UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.
UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.
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DOI：
10.1016/j.mad.2012.06.004
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发表时间：
2012-08
影响因子：
5.3
通讯作者：
Christiansen, Lene
中科院分区：
文献类型：
--
作者：
Dato, Serena;Soerensen, Mette;Montesanto, Alberto;Lagani, Vincenzo;Passarino, Giuseppe;Christensen, Kaare;Christiansen, Lene
有效的解偶联过程通常被认为通过减缓其与年龄相关的衰退对老化肌肉具有保护作用。解偶联蛋白3（UCP3）基因的遗传多态性，其产物主要在骨骼肌中表达，被认为与老年人群的握力（HG）性能相关。考虑到老龄化质量的人群特异性，我们的目的是通过分析UCP3基因中的四个SNP与两个大型队列中年人（N = 708）和最年长的老年丹麦人（N = 908）中的相对单倍型之间的关联来进一步支持这一证据。我们发现，在两个队列中，rs1685354和rs11235972的变异性与单个和单倍型水平的HG水平相关。此外，利用最老队列的大队列和时期生存数据，我们测试了每个SNP与基线访视后10年生存率的相关性。有趣的是，我们发现rs11235972处的等位基因A，在该队列中与最低的HG评分相关，也影响生存模式，携带该等位基因的人显示出更高的死亡率。总体而言，我们的工作支持UCP3基因在老年功能状态和生存中的作用。
An efficient uncoupling process is generally considered to have a protective effect on the aging muscle by slowing down its age-related decay. Genetic polymorphisms in the Uncoupling Protein 3 (UCP3) gene, whose product is mainly expressed in skeletal muscle, were suggested to be associated with hand grip (HG) performances in elderly populations. Considering the population specificity of the quality of aging, we aimed to add further support to this evidence by analyzing the association between four SNPs in the UCP3 gene and relative haplotypes in two large cohorts of middle aged (N = 708) and oldest old Danes (N = 908). We found that the variability at rs1685354 and rs11235972 was associated with HG levels both at single and haplotypic level in both cohorts. Furthermore, taking advantage of large cohort and period survival data of the oldest cohort, we tested the association of each SNP with survival at 10 years from the baseline visit. Interestingly, we found that allele A at rs11235972, associated in this cohort with lowest HG scores, influences also the survival patterns, with people carrying this allele showing higher mortality rates. On the whole, our work supports the role of UCP3 gene in functional status and survival at old age.
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DOI：
10.1073/pnas.0804931105
发表时间：
2008-09-09
影响因子：
11.1
作者：
Christensen, Kaare;McGue, Matt;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
120.7
作者：
Rantanen, T;Guralnik, JM;White, L
通讯作者：
White, L
DOI：
10.1111/j.1532-5415.2006.00693.x
发表时间：
2006-05-01
影响因子：
6.3
作者：
Arking, Dan E.;Fallin, Daniele M.;Walston, Jeremy
通讯作者：
Walston, Jeremy
DOI：
10.1093/gerona/61.7.707
发表时间：
2006-07-01
影响因子：
5.1
作者：
Jeune, Bernard;Skytthe, Axel;Robine, Jean-Marie
通讯作者：
Robine, Jean-Marie
DOI：
10.1067/mlc.2001.113504
发表时间：
2001-04-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Morley, JE;Baumgartner, RN;Nair, KS
通讯作者：
Nair, KS