A bilayered PLGA/multiwall carbon nanotubes/bacterial cellulose composite membrane for tissue regeneration of maxillary canine periodontal bone defects

A bilayered PLGA/multiwall carbon nanotubes/bacterial cellulose composite membrane for tissue regeneration of maxillary canine periodontal bone defects
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双层PLGA/多壁碳纳米管/细菌纤维素复合膜用于上颌犬牙周骨缺损的组织再生

DOI:
10.1016/j.matlet.2017.10.058
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发表时间:
2018-02
期刊:
影响因子:
3
通讯作者:
Xu Lihua
Xu Lihua
中科院分区:
材料科学3区
文献类型:
--
作者:
Zhang Hualin;Wang Juan;Wang Kairong;Xu Lihua

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采用真空冷冻干燥和静电纺丝技术制备了聚乳酸-羟基乙酸共聚物(PLGA)/多壁碳纳米管(MWNTs)/细菌纤维素(BC)双层复合膜,并将其作为引导组织再生(GTR)膜修复Beagle犬上颌尖牙牙周缺损。进行形态学和组织学观察和分析以表征膜。该双层膜由下层纤维状BC膜层和上层静电纺丝PLGA/MWNTs膜层组成,具有三维网络结构。组织学结果表明,双层膜促进牙周组织再生。BC/PLGA/MWNTs膜是一种理想的GTR膜,在牙周病治疗中具有潜在的应用价值。
A bilayered polylactic-co-glycolic acid (PLGA)/multiwall carbon nanotubes (MWNTs)/bacterial cellulose (BC) composite membrane was prepared by vacuum freeze-drying and electrospinning for use as a guided tissue regeneration (GTR) membrane to repair maxillary canine periodontal defects in beagle dogs. Morphological and histological observations and analyses were performed to characterize the membrane. The bilayered membrane comprised a lower fibrous BC film layer and an upper electrospun PLGA/MWNTs film layer with a three-dimensional network structure. The histological results showed that the bilayered membrane promoted periodontal tissue regeneration. The BC/PLGA/MWNTs membrane may be an ideal GTR membrane candidate and thus has potential therapeutic applications in periodontal disease.
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发表时间: 2010-05-05
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