Suppression of neutrophil recruitment in mice by geranium essential oil.
Suppression of neutrophil recruitment in mice by geranium essential oil.
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DOI：
10.1080/09629350410001664798
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发表时间：
2004-02
影响因子：
4.6
通讯作者：
Yamaguchi H
中科院分区：
文献类型：
--
作者：
Abe S;Maruyama N;Hayama K;Inouye S;Oshima H;Yamaguchi H
背景技术背景：在芳香疗法中，精油被用作抗炎药物，但对其作用机制的实验研究非常有限。研究目的：为了评估它们的抗炎活性，在体内检查了精油对小鼠中性粒细胞募集的影响。实验方法：研究了精油对小鼠腹腔注射酪蛋白后6 h诱导的白细胞和中性粒细胞募集的影响。研究结果：以5 μ l/只小鼠的剂量腹腔内注射天竺葵、柠檬草和留兰香油，可抑制小鼠腹腔内白细胞的募集，但茶树油不能抑制。这种招募被抑制剂量依赖性的香叶油。抑制白细胞募集是由于抑制中性粒细胞蓄积。结论：某些精油作为抗炎药物可抑制中性粒细胞向小鼠腹腔的募集。
BACKGROUND: In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY: To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD: The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined. RESULTS: Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 microl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation. CONCLUSION: Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.
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影响因子：
4.6
作者：
Abe, S;Maruyama, N;Yamaguchi, H
通讯作者：
Yamaguchi, H
影响因子：
6.7
作者：
Brand, C;Townley, SL;Hart, PH
通讯作者：
Hart, PH
影响因子：
6.7
作者：
Brand, C;Ferrante, A;Hart, PH
通讯作者：
Hart, PH
影响因子：
6.7
作者：
Brand, C;Grimbaldeston, MA;Hart, PH
通讯作者：
Hart, PH
影响因子：
3.3
作者：
Kim, HM;Cho, SH
通讯作者：
Cho, SH