Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism.
Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism.
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DOI：
10.1007/s10803-008-0653-8
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发表时间：
2009-03
影响因子：
3.9
通讯作者：
Stevens, Hanna E.
中科院分区：
文献类型：
--
作者：
Vaccarino, Flora M.;Grigorenko, Elena L.;Smith, Karen Muller;Stevens, Hanna E.
关键词：
患有自闭症谱系障碍的儿童大脑体积增大很常见。在这里，我们提出，皮质兴奋性神经元数量的增加可能是脑容量增加、微柱病理学和过度网络兴奋性的基础，导致感觉过度反应和癫痫发作，这在自闭症中常见。我们认为，成纤维细胞生长因子（FGF）是调节皮质大小和连接性的基因家族，可能是这些发育改变的原因。动物模型研究表明，FGF 基因突变会导致皮质体积、兴奋性皮质神经元数量、微柱病理、多动症和社交缺陷的改变。因此，许多危险因素可能集中在 FGF 调节的发病途径上，从而改变兴奋/抑制平衡和皮质模块结构，并易患自闭症谱系障碍。
Increased brain size is common in children with autism spectrum disorders. Here we propose that an increased number of cortical excitatory neurons may underlie the increased brain volume, minicolumn pathology and excessive network excitability, leading to sensory hyper-reactivity and seizures, which are often found in autism. We suggest that Fibroblast Growth Factors (FGF), a family of genes that regulate cortical size and connectivity, may be responsible for these developmental alterations. Studies in animal models suggest that mutations in FGF genes lead to altered cortical volume, excitatory cortical neuron number, minicolum pathology, hyperactivity and social deficits. Thus, many risk factors may converge upon FGF-regulated pathogenetic pathways, which alter excitatory/inhibitory balance and cortical modular architecture, and predispose to autism spectrum disorders.
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