Enhanced antioxidant capacity and anti-ageing biomarkers after diet micronutrient supplementation.
Enhanced antioxidant capacity and anti-ageing biomarkers after diet micronutrient supplementation.
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DOI：
10.3390/molecules190914794
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发表时间：
2014-09-17
期刊：
影响因子：
--
通讯作者：
Szemraj J
中科院分区：
文献类型：
--
作者：
Balcerczyk A;Gajewska A;Macierzyńska-Piotrowska E;Pawelczyk T;Bartosz G;Szemraj J
越来越多的研究证实，饮食、生活方式和体育活动对健康状况、衰老过程和许多代谢紊乱有重要影响。这项研究的重点是饮食补充剂NucleVital®Q10 Complex对氧化还原稳态和衰老相关参数的影响。一个由66名年龄在35-55岁之间的健康志愿者组成的实验组在12周的时间里用这种含有欧米伽-3酸的复合物补充饮食（1350毫克/天），泛醌（300毫克/天），虾青素（15毫克/天），番茄红素（45毫克/天），叶黄素棕榈酸酯（30 mg/天）、玉米黄嘌呤棕榈酸酯（6 mg/天）、L-硒代蛋氨酸（330 mg/天）、胆钙化醇（30 µg/天）和α-生育酚（45 mg/天）。我们发现，补充NucleVital®Q10复合物显著增加了血浆的总抗氧化能力和红细胞超氧化物歧化酶的活性，对红细胞中的氧化应激生物标志物、MDA和4-羟基烯烃水平有轻微影响。除了观察到的抗氧化作用外，测试的补充剂还显示出抗衰老活性。SIRT 1和2在PBMC中的表达分析表明，这两个基因在mRNA水平上的显着变化。端粒酶水平也增加了25%以上，虽然淋巴细胞端粒的长度，通过RT-PCR测定，保持不变。我们的研究结果表明，即使在短期补充NucleVital®Q10 Complex饮食后，血浆的抗氧化潜力以及与衰老相关的生物标志物也具有有益效果。
A growing number of studies confirm an important effect of diet, lifestyle and physical activity on health status, the ageing process and many metabolic disorders. This study focuses on the influence of a diet supplement, NucleVital®Q10 Complex, on parameters related to redox homeostasis and ageing. An experimental group of 66 healthy volunteer women aged 35–55 supplemented their diet for 12 weeks with the complex, which contained omega-3 acids (1350 mg/day), ubiquinone (300 mg/day), astaxanthin (15 mg/day), lycopene (45 mg/day), lutein palmitate (30 mg/day), zeaxanthine palmitate (6 mg/day), L-selenomethionine (330 mg/day), cholecalciferol (30 µg/day) and α-tocopherol (45 mg/day). We found that NucleVital®Q10 Complex supplementation significantly increased total antioxidant capacity of plasma and activity of erythrocyte superoxide dismutase, with slight effects on oxidative stress biomarkers in erythrocytes; MDA and 4-hydroxyalkene levels. Apart from the observed antioxidative effects, the tested supplement also showed anti-ageing activity. Analysis of expression of SIRT1 and 2 in PBMCs showed significant changes for both genes on a mRNA level. The level of telomerase was also increased by more than 25%, although the length of lymphocyte telomeres, determined by RT-PCR, remained unchanged. Our results demonstrate beneficial effects concerning the antioxidant potential of plasma as well as biomarkers related to ageing even after short term supplementation of diet with NucleVital®Q10 Complex.
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DOI：
10.18632/aging.100299
发表时间：
2011-03
期刊：
Aging
影响因子：
--
作者：
Ha CW;Huh WK
通讯作者：
Huh WK
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM
影响因子：
4
作者：
Kirkwood, Thomas B. L.;Kowald, Axel
通讯作者：
Kowald, Axel
影响因子：
2.7
作者：
Komulainen, Pirjo;Pedersen, Maria;Rauramaa, Rainer
通讯作者：
Rauramaa, Rainer
咖啡酸苯乙酯和维生素E联合使用增强抗辐射诱导氧化应激的抗氧化作用
影响因子：
5.1
作者：
Bai, Hua;Liu, Rui;Hai, Chun-Xu
通讯作者：
Hai, Chun-Xu