Early exposure to volatile anesthetics impairs long-term associative learning and recognition memory.
Early exposure to volatile anesthetics impairs long-term associative learning and recognition memory.
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早期暴露于挥发性麻醉药会损害长期的关联学习和识别记忆。
DOI：
10.1371/journal.pone.0105340
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sall JW
中科院分区：
文献类型：
--
作者：
Lee BH;Chan JT;Hazarika O;Vutskits L;Sall JW
生命早期接触麻醉剂会影响神经发育和长期认知功能，但我们对改变的记忆类型的理解并不完整。对啮齿动物进行特定的认知测试，隔离不同的记忆过程，为深入了解这个问题提供了一种有用的方法。出生后第 7 天 (P7) 大鼠暴露于 1 个最低肺泡浓度的地氟烷或异氟烷 4 小时。 12小时后评估丘脑、海马CA1-3区域和齿状回的急性神经元死亡。在从 P48 开始的单独行为实验中，受试者在一系列依赖于联想学习和社会识别的物体识别测试中进行了评估。暴露于任何一种麻醉剂都会导致每个大脑区域的神经细胞凋亡显着增加。神经元死亡的程度在各组之间没有差异。受试者在新物体和物体位置识别的简单任务中不受影响。然而，两组麻醉动物的异中心物体位置记忆和更复杂的任务都受到损害，该任务要求受试者将物体与其位置和背景环境联系起来。接触异氟烷会导致物体-情境关联和社会记忆的额外损害。发育过程中接触异氟醚和地氟醚会导致依赖联想学习和识别记忆的任务缺陷。异氟烷可能会比地氟烷造成更严重的损害。
Anesthetic exposure early in life affects neural development and long-term cognitive function, but our understanding of the types of memory that are altered is incomplete. Specific cognitive tests in rodents that isolate different memory processes provide a useful approach for gaining insight into this issue. Postnatal day 7 (P7) rats were exposed to either desflurane or isoflurane at 1 Minimum Alveolar Concentration for 4 h. Acute neuronal death was assessed 12 h later in the thalamus, CA1-3 regions of hippocampus, and dentate gyrus. In separate behavioral experiments, beginning at P48, subjects were evaluated in a series of object recognition tests relying on associative learning, as well as social recognition. Exposure to either anesthetic led to a significant increase in neuroapoptosis in each brain region. The extent of neuronal death did not differ between groups. Subjects were unaffected in simple tasks of novel object and object-location recognition. However, anesthetized animals from both groups were impaired in allocentric object-location memory and a more complex task requiring subjects to associate an object with its location and contextual setting. Isoflurane exposure led to additional impairment in object-context association and social memory. Isoflurane and desflurane exposure during development result in deficits in tasks relying on associative learning and recognition memory. Isoflurane may potentially cause worse impairment than desflurane.
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影响因子：
2
作者：
Eacott, MJ;Easton, A;Zinkivskay, A
通讯作者：
Zinkivskay, A
DOI：
10.1016/j.brainresprot.2005.08.001
发表时间：
2005-12-01
期刊：
BRAIN RESEARCH PROTOCOLS
影响因子：
--
作者：
Dere, E;Huston, JP;Silva, MAS
通讯作者：
Silva, MAS
影响因子：
2.7
作者：
Kart-Teke, E;Silva, MADS;Dere, E
通讯作者：
Dere, E
影响因子：
5.7
作者：
DiMaggio C;Sun LS;Li G
通讯作者：
Li G
影响因子：
5.3
作者：
Eacott, MJ;Norman, G
通讯作者：
Norman, G