Sponges and Their Symbionts as a Source of Valuable Compounds in Cosmeceutical Field.
Sponges and Their Symbionts as a Source of Valuable Compounds in Cosmeceutical Field.
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DOI：
10.3390/md19080444
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发表时间：
2021-08-02
期刊：
影响因子：
5.4
通讯作者：
Costantini M
中科院分区：
文献类型：
--
作者：
Esposito R;Ruocco N;Viel T;Federico S;Zupo V;Costantini M
在过去的几十年里，海洋环境被发现是一个巨大的新型生物活性化合物的储存库，可用于改善人类健康和福祉的药物治疗。根据每年描述新分子的大量文献，在几种具有生物技术潜力的海洋生物中，海绵被强调为最有趣的门之一。毫不奇怪，第一批被批准用于医疗目的的海洋药物是从海绵中分离出来的，现在被用作抗癌和抗病毒药物。在大多数情况下，实验证据报告说，经常关联和/或共生社区产生这些生物活性化合物的互利。如今，利用海洋新型化合物所发挥的有益特性来配制美容护理。事实上，记录了几种适用于美容处理的生物活性，例如抗氧化剂、抗衰老、皮肤增白和乳化活性等。在这里，我们收集和讨论了几个科学贡献报告的药用海绵共生体的潜力，这是专门代表真菌和细菌。还包括特别指明为海绵代谢产物的生物活性化合物。然而，海绵代谢物的来源是可疑的，不能排除相关生物群的作用，考虑到共生体的分离是一个艰难的挑战，由于其不可培养的特点。
In the last decades, the marine environment was discovered as a huge reservoir of novel bioactive compounds, useful for medicinal treatments improving human health and well-being. Among several marine organisms exhibiting biotechnological potential, sponges were highlighted as one of the most interesting phyla according to a wide literature describing new molecules every year. Not surprisingly, the first marine drugs approved for medical purposes were isolated from a marine sponge and are now used as anti-cancer and anti-viral agents. In most cases, experimental evidence reported that very often associated and/or symbiotic communities produced these bioactive compounds for a mutual benefit. Nowadays, beauty treatments are formulated taking advantage of the beneficial properties exerted by marine novel compounds. In fact, several biological activities suitable for cosmetic treatments were recorded, such as anti-oxidant, anti-aging, skin whitening, and emulsifying activities, among others. Here, we collected and discussed several scientific contributions reporting the cosmeceutical potential of marine sponge symbionts, which were exclusively represented by fungi and bacteria. Bioactive compounds specifically indicated as products of the sponge metabolism were also included. However, the origin of sponge metabolites is dubious, and the role of the associated biota cannot be excluded, considering that the isolation of symbionts represents a hard challenge due to their uncultivable features.
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影响因子：
5.4
作者：
Adu SA;Naughton PJ;Marchant R;Banat IM
通讯作者：
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影响因子：
7.3
作者：
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影响因子：
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影响因子：
3
作者：
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