Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.
Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.
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DOI：
10.1186/s12933-014-0129-4
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发表时间：
2014-09-26
影响因子：
9.3
通讯作者：
Saravanan P
中科院分区：
文献类型：
--
作者：
Adaikalakoteswari A;Jayashri R;Sukumar N;Venkataraman H;Pradeepa R;Gokulakrishnan K;Anjana RM;McTernan PG;Tripathi G;Patel V;Kumar S;Mohan V;Saravanan P
二甲双胍是2型糖尿病的标准疗法，可降低维生素B12水平。研究表明，维生素B12水平低与心血管疾病之间的联系是模棱两可的，提高维生素B12水平可能有助于一级预防。维生素B12缺乏对心血管危险因素的作用，特别是在2型糖尿病中尚未探讨。本研究的目的是调查英国和印度两个不同种族的2型糖尿病患者中维生素B12缺乏是否与心血管危险因素相关。研究了来自两个二级糖尿病护理中心（欧洲人-英国和印度人-印度）的2型糖尿病患者。测定血清维生素B12、叶酸及生化指标。欧洲人和印度人维生素B12缺乏症（<191 ng/L）的患病率分别为27%和12%，二甲双胍治疗的2型糖尿病患者的患病率更高。在线性回归分析中，在调整所有可能的混杂因素后，维生素B12与两个人群中的甘油三酯和印度人的胆固醇/HDL比率独立相关。Logistic回归分析显示，在调整所有可能的混杂因素后，欧洲人中维生素B12缺乏的2型糖尿病患者并发冠状动脉疾病（CAD）的几率显著较高，印度人的趋势相似但不显著。维生素B12缺乏症在2型糖尿病患者中很常见，并与不良血脂参数相关。2型糖尿病管理指南应包括定期检测B12水平的建议，特别是对于那些二甲双胍。本文的在线版本（doi：10.1186/s12933-014-0129-4）包含补充材料，可供授权用户使用。
Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. Type 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured. The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients. In linear regression analysis, after adjusting for all likely confounding factors, vitamin B12 independently associated with triglycerides in both the populations and cholesterol/HDL ratio in Indians. Logistic regression showed type 2 diabetes patients with vitamin B12 deficiency were at significantly higher odds of having coexisting coronary artery disease (CAD) in Europeans with similar but non-significant trend in Indians, after adjusting for all likely confounding factors. The prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin. The online version of this article (doi:10.1186/s12933-014-0129-4) contains supplementary material, which is available to authorized users.
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影响因子：
4.4
作者：
MCCOMBE, PA;MCLEOD, JG
通讯作者：
MCLEOD, JG
影响因子：
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作者：
BRINDLE, NPJ;ZAMMIT, VA;POGSON, CI
通讯作者：
POGSON, CI
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作者：
Chackathayil, Julia;Patel, Jeetesh V.;Lip, Gregory Y. H.
通讯作者：
Lip, Gregory Y. H.
影响因子：
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作者：
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通讯作者：
MCKEIGUE, PM
影响因子：
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作者：
Shargorodsky, M.;Boaz, M.;Mashavi, M.
通讯作者：
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