In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.
In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.
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体内纳米颗粒介导的放射性药物激发荧光分子成像
DOI：
10.1038/ncomms8560
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发表时间：
2015-06-30
影响因子：
16.6
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Hu, Zhenhua;Qu, Yawei;Wang, Kun;Zhang, Xiaojun;Zha, Jiali;Song, Tianming;Bao, Chengpeng;Liu, Haixiao;Wang, Zhongliang;Wang, Jing;Liu, Zhongyu;Liu, Haifeng;Tian, Jie
切伦科夫发光成像利用放射性药物发射的可见光子来实现体内光学分子衍生信号。由于切伦科夫辐射很弱，对于组织穿透来说不是最佳的，并且无论生物相互作用如何都是连续的，因此用诊断剂量检测这种信号是具有挑战性的。因此，实现用于获取直接分子信息的有用的活化光学成像是具有挑战性的。在这里，我们介绍了一种新的成像策略，通过氧化铕纳米颗粒将放射性同位素的γ和切伦科夫辐射转化为荧光。经过一系列的成像研究，我们证明，这种方法提供了强大的光信号与高信号背景比，一个理想的组织穿透光谱和可激活的成像能力。与目前的成像技术相比，它可以更有效地检测低放射性示踪剂摄取的肿瘤病变或小肿瘤病变。我们相信，它将促进核和光学分子成像的发展，为新的，高灵敏度的成像应用。 成像灵敏度不足可能使评估体内早期肿瘤病变具有挑战性。在这里，作者提出了放射性药物激发的荧光成像技术，可以检测活体小鼠中小于2 mm的肿瘤病变。
Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. Insufficient imaging sensitivity can make it challenging to assess early stage tumour lesions in vivo. Here, the authors present the radiopharmaceutical-excited fluorescence imaging technique that can detect tumour lesions less than 2 mm in size in living mice.
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Er3、Yb3掺杂稀土微粒双激发增强切伦科夫发光成像
影响因子：
3.7
作者：
Ma X;Kang F;Xu F;Feng A;Zhao Y;Lu T;Yang W;Wang Z;Lin M;Wang J
通讯作者：
Wang J
DOI：
10.1007/s00259-014-2689-7
发表时间：
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作者：
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影响因子：
3.7
作者：
Liu H;Ren G;Miao Z;Zhang X;Tang X;Han P;Gambhir SS;Cheng Z
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影响因子：
9.3
作者：
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