Integration of Parallel Opposing Memories Underlies Memory Extinction.
Integration of Parallel Opposing Memories Underlies Memory Extinction.
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DOI：
10.1016/j.cell.2018.08.021
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发表时间：
2018-10-18
期刊：
影响因子：
64.5
通讯作者：
Waddell S
中科院分区：
文献类型：
--
作者：
Felsenberg J;Jacob PF;Walker T;Barnstedt O;Edmondson-Stait AJ;Pleijzier MW;Otto N;Schlegel P;Sharifi N;Perisse E;Smith CS;Lauritzen JS;Costa M;Jefferis GSXE;Bock DD;Waddell S
准确预测结果需要动物从连续的经验中学习支持和冲突的证据。在哺乳动物和无脊椎动物中，习得性恐惧反应可以通过经历预测线索而不受惩罚来抑制，这一过程称为记忆消退。在这里，我们表明，在果蝇的厌恶性记忆的灭绝需要特定的多巴胺能神经元，这表明，惩罚的遗漏记住作为一个积极的经验。功能成像显示，在蘑菇体输出神经元网络的不同地方，原始的厌恶记忆和一个新的食欲消退记忆的细胞内钙的痕迹共存。光和超微结构解剖学是一致的平行竞争的记忆被结合在蘑菇体输出神经元，直接避免。事实上，这些神经元中的一对神经元中的嗅觉诱发的可塑性中和了厌恶学习在网络中施加的增强的气味反应。因此，苍蝇通过积累和整合冲突事件的记忆来跟踪学习期望的准确性。预期惩罚的省略会导致学习性回避行为缺乏惩罚是作为一种积极的经验而学习的最初的厌恶记忆和新的欲望记忆在不同的地方共存对立的记忆被整合到特定的输出神经元中以引导行为惩罚的省略被记住作为一种奖励的经验，这种积极的记忆然后与先前的厌恶记忆竞争以调解回避行为的消失。
Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of aversive memories in Drosophila requires specific dopaminergic neurons, which indicate that omission of punishment is remembered as a positive experience. Functional imaging revealed co-existence of intracellular calcium traces in different places in the mushroom body output neuron network for both the original aversive memory and a new appetitive extinction memory. Light and ultrastructural anatomy are consistent with parallel competing memories being combined within mushroom body output neurons that direct avoidance. Indeed, extinction-evoked plasticity in a pair of these neurons neutralizes the potentiated odor response imposed in the network by aversive learning. Therefore, flies track the accuracy of learned expectations by accumulating and integrating memories of conflicting events. Omission of expected punishment extinguishes learned avoidance behavior Lack of punishment is learned as a positive experience The original aversive and the new appetitive memory co-exist in different places Opposing memories are integrated within specific output neurons to steer behavior The omission of punishment is remembered as a rewarding experience, and this positive memory then competes against prior aversive memory to mediate the extinction of avoidance behavior.
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影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
56.9
作者：
Berman, DE;Dudai, Y
通讯作者：
Dudai, Y
DOI：
10.1007/bf00656809
发表时间：
1977-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
DUDAI, Y
通讯作者：
DUDAI, Y
影响因子：
64.5
作者：
Gore F;Schwartz EC;Brangers BC;Aladi S;Stujenske JM;Likhtik E;Russo MJ;Gordon JA;Salzman CD;Axel R
通讯作者：
Axel R
影响因子：
64.8
作者：
Grewe BF;Gründemann J;Kitch LJ;Lecoq JA;Parker JG;Marshall JD;Larkin MC;Jercog PE;Grenier F;Li JZ;Lüthi A;Schnitzer MJ
通讯作者：
Schnitzer MJ