Association between depression and anxiety in high-functioning children with autism spectrum disorders and maternal mood symptoms.
Association between depression and anxiety in high-functioning children with autism spectrum disorders and maternal mood symptoms.
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DOI：
10.1002/aur.133
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发表时间：
2010-06
期刊：
影响因子：
4.7
通讯作者：
Oswald, Donald P.
中科院分区：
文献类型：
--
作者：
Mazefsky, Carla A.;Conner, Caitlin M.;Oswald, Donald P.
关键词：
研究表明，患有自闭症谱系障碍（asd）的儿童及其亲属有很高的抑郁和焦虑率。然而，相对较少的研究同时考虑了这两个因素。本研究考察了母亲情绪症状与ASD患儿抑郁和焦虑之间的潜在关系。参与者是31名10到17岁的儿童，他们被诊断为ASD，并得到了金标准测量和他们的生母的支持。母亲们完成了自闭症共病访谈，以确定患有ASD的孩子是否符合任何抑郁或焦虑诊断的标准，并填写了一份关于她们自己当前情绪症状的问卷。正如预期的那样，许多患有ASD的儿童符合抑郁症（32%）和焦虑症（39%）的终身诊断标准。母亲们对自己当前情绪症状的报告显示，平均值在正常范围内，尽管存在显著的差异。根据母亲的人际关系敏感、敌意、恐惧性焦虑、抑郁和焦虑等症状，大约75%的ASD儿童可以正确地归类为有抑郁或焦虑障碍史或没有抑郁或焦虑史。这些结果提供了初步证据，表明母亲的情绪症状可能与ASD患儿的抑郁和焦虑有关。虽然设计本身不允许测试遗传性，但家族传播模式与典型人群的研究总体上是一致的。虽然需要更大规模的后续研究，但这项研究对预防和干预工作具有启示意义。
Research suggests that children with autism spectrum disorders (ASDs) and their relatives have high rates of depression and anxiety. However, relatively few studies have looked at both factors concurrently. This study examined the potential relationship between maternal mood symptoms and depression and anxiety in their children with ASD. Participants were 31 10- to 17-year-old children with an ASD diagnosis that was supported by gold-standard measures and their biological mothers. Mothers completed the Autism Comorbidity Interview to determine whether the child with ASD met criteria for any depressive or anxiety diagnoses and a questionnaire of their own current mood symptoms. As expected, many children with ASD met criteria for lifetime diagnoses of depressive (32%) and anxiety disorders (39%). Mothers’ report of their own current mood symptoms revealed averages within the normal range, though there was significant variability. Approximately 75% of children with ASD could be correctly classified as having a depressive or anxiety disorder history or not based on maternal symptoms of interpersonal sensitivity, hostility, phobic anxiety, depression, and anxiety. The results provide preliminary evidence that maternal mood symptoms may be related to depression and anxiety in their children with ASD. Although the design did not allow for testing of heritability per se, the familial transmission patterns were generally consistent with research in typical populations. While larger follow-up studies are needed, this research has implications for prevention and intervention efforts.
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