Dissociable roles of medial and lateral PFC in rule learning.

Dissociable roles of medial and lateral PFC in rule learning.
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内侧和外侧 PFC 在规则学习中的分离作用

DOI:
10.1002/brb3.551
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发表时间:
2016-11
期刊:
影响因子:
3.1
通讯作者:
Li, Hong
Li, Hong
中科院分区:
心理学4区
文献类型:
--
作者:
Cao, Bihua;Li, Wei;Li, Fuhong;Li, Hong

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尽管认知神经科学家对规则学习的神经基础非常感兴趣,但规则发现过程中的瞬时大脑激活模式仍有待研究。在这项研究中,我们测量了规则学习不同阶段的事件相关功能磁共振成像(fMRI)。21名健康的志愿者被出示了一系列卡片,每张卡片上都有一个类似时钟的12个圆圈,按顺序编号。参与者被告知,一个虚构的动物将从一个圆圈移动到另一个圆圈,要么以规则模式(根据连续试验中隐藏的规则),要么随机移动。然后,参与者被要求判断给定的步骤是否遵循规则。虽然规则搜索阶段在后外侧前额叶皮层(LPFC)中引起了更多的激活,但规则遵循阶段在前内侧前额叶皮层(MPFC)中引起了更强的激活。重要的是,中间阶段,规则发现阶段在MPFC和背侧前扣带皮层(dACC)中引起的激活比规则搜索更多,在LPFC中引起的激活比规则遵循更多。因此,我们可以得出结论,内侧和外侧PFC在规则学习中的贡献是分开的。
Although the neural basis of rule learning is of great interest to cognitive neuroscientists, the pattern of transient brain activation during rule discovery remains to be investigated. In this study, we measured event‐related functional magnetic resonance imaging (fMRI) during distinct phases of rule learning. Twenty‐one healthy human volunteers were presented with a series of cards, each containing a clock‐like display of 12 circles numbered sequentially. Participants were instructed that a fictitious animal would move from one circle to another either in a regular pattern (according to a rule hidden in consecutive trials) or randomly. Participants were then asked to judge whether a given step followed a rule. While the rule‐search phase evoked more activation in the posterior lateral prefrontal cortex (LPFC), the rule‐following phase caused stronger activation in the anterior medial prefrontal cortex (MPFC). Importantly, the intermediate phase, the rule‐discovery phase evoked more activations in MPFC and dorsal anterior cingulate cortex (dACC) than rule search, and more activations in LPFC than rule following. Therefore, we can conclude that the medial and lateral PFC have dissociable contributions in rule learning.
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