The Effect of Smoking during Pregnancy on Severity and Directionality of Externalizing and Internalizing Symptoms: A Genetically Informed Approach.
The Effect of Smoking during Pregnancy on Severity and Directionality of Externalizing and Internalizing Symptoms: A Genetically Informed Approach.
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DOI：
10.3390/ijerph17217921
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发表时间：
2020-10-28
影响因子：
--
通讯作者：
Knopik VS
中科院分区：
文献类型：
--
作者：
Ekblad MO;Marceau K;Rolan E;Palmer RHC;Todorov A;Heath AC;Knopik VS
目的是检查母亲在怀孕期间吸烟 (SDP) 与兄弟姐妹样本中外化和内化症状的严重性和方向性之间的关联，同时严格控制家族混杂因素。密苏里州母亲及其子女研究是一项家庭研究（N = 173 个家庭），其中的兄弟姐妹对（7 至 16 岁）在 SDP 暴露方面不一致。这项兄弟姐妹比较研究旨在阐明 SDP 与家庭混杂因素的影响。使用 SDP 指标（时间、持续时间和数量）的组合为每个孩子创建 SDP 严重性评分。外化和内化行为的主成分分析，通过儿童行为检查表和教师报告表进行评估，用于创建症状严重程度和方向性评分。严重性和方向性得分的差异主要是兄弟姐妹之间差异的函数（分别为 71% 和 85%），而不是家庭之间的差异（分别为 29% 和 15%）。结合外化和内化症状严重程度的严重程度评分与 SDP 无关。然而，在兄弟姐妹比较模型中观察到 SDP 对症状方向性有显着的家庭内影响（b = 0.07，p = 0.04）。正方向性评分表明，在用兄弟姐妹比较模型控制家族混杂因素后，SDP 与症状向外化症状的分化相关，而不是与内化症状相关。这支持了 SDP 和外化行为之间的潜在因果关系。
The objective was to examine the association between maternal smoking during pregnancy (SDP) and (I) severity and (II) directionality of externalizing and internalizing symptoms in a sample of sibling pairs while rigorously controlling for familial confounds. The Missouri Mothers and Their Children Study is a family study (N = 173 families) with sibling pairs (aged 7 to 16 years) who are discordant for exposure to SDP. This sibling comparison study is designed to disentangle the effects of SDP from familial confounds. An SDP severity score was created for each child using a combination of SDP indicators (timing, duration, and amount). Principal component analysis of externalizing and internalizing behavior, assessed with the Child Behavior Checklist and Teacher Report Form, was used to create symptom severity and directionality scores. The variance in severity and directionality scores was primarily a function of differences between siblings (71% and 85%, respectively) rather than differences across families (29% and 15%, respectively). The severity score that combines externalizing and internalizing symptom severity was not associated with SDP. However, a significant within-family effect of SDP on symptom directionality (b = 0.07, p = 0.04) was observed in the sibling comparison model. The positive directionality score indicates that SDP is associated with differentiation of symptoms towards externalizing rather than internalizing symptoms after controlling for familial confounds with a sibling comparison model. This supports a potentially causal relationship between SDP and externalizing behavior.
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DOI：
10.1097/chi.0b013e318172eefb
发表时间：
2008-07-01
影响因子：
13.3
作者：
Ashford, Janka;van Lier, Pol A. C.;Koot, Hans M.
通讯作者：
Koot, Hans M.
影响因子：
4.7
作者：
Ekblad, Mikael O.;Rolan, Emily;Knopik, Valerie S.
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Knopik, Valerie S.
DOI：
10.1017/thg.2015.46
发表时间：
2015-10
期刊：
Twin research and human genetics : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Knopik VS;Heath AC;Marceau K;Palmer RH;McGeary JE;Todorov A;Evans AS
通讯作者：
Evans AS
DOI：
10.1093/ntr/ntx001
发表时间：
2017-05-01
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Ekblad M;Lehtonen L;Korkeila J;Gissler M
通讯作者：
Gissler M
影响因子：
3.6
作者：
Marceau K;Cinnamon Bidwell L;Karoly HC;Evans AS;Todorov AA;Palmer RH;Heath AC;Knopik VS
通讯作者：
Knopik VS