Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome.
Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome.
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DOI：
10.1080/15374416.2013.843462
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hessl D
中科院分区：
文献类型：
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作者：
Cohen S;Masyn K;Mastergeorge A;Hessl D
Individuals with autism demonstrate atypical and variable responses to social and emotional stimuli, perhaps reflecting heterogeneity of the disorder. The goal of this study was to determine whether unique profiles of psychophysiological responses to such stimuli could be identified in individuals diagnosed with autism, with fragile X syndrome, with comorbid autism and fragile X syndrome, and typically developing males. This study included 52 boys (ages 10–17): idiopathic autism (ASD; n=12), fragile X syndrome (FXS; n=12), comorbid autism and fragile X syndrome (ASD+FXS; n=17), typically developing (TYP; n=11). Physiological responses, including potentiated startle, electrodermal response, heart rate variability, and vagal tone were collected concurrently while participants viewed emotionally evocative pictures of human faces or non-social images. While some of these measures have been utilized separately for investigations on these diagnostic groups, they have not been considered together. Results of Kruskal-Wallis one-way analysis of variance by ranks indicate statistically significant differences in distributions of autonomic regulation responses between groups. The most notable differences were between the ASD group and both the fragile X groups on measures of sympathetic activity, with fragile X groups evincing increased activity. Also, both the autism and ASD+FXS groups showed significantly decreased parasympathetic activity compared with FXS and TYP groups. Additionally, the ASD+FXS group demonstrated a unique distribution of startle potentiation and arousal modulation. This study provides evidence that autonomic arousal and regulation profiles could be useful to distinguishing subgroups of autism and shed light on the variability underlying emotional responsivity.
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DOI：
10.1098/rstb.1997.0149
发表时间：
1997-11-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
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作者：
Davis, M;Walker, DL;Lee, Y
通讯作者：
Lee, Y
DOI：
10.1037//0097-7403.4.2.95
发表时间：
1978-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
DAVIS, M;ASTRACHAN, DI
通讯作者：
ASTRACHAN, DI
影响因子：
10.6
作者：
Althaus, M;Mulder, LJM;Minderaa, RB
通讯作者：
Minderaa, RB
影响因子：
17.1
作者：
Berry-Kravis, Elizabeth M.;Hessl, David;Hagerman, Randi J.
通讯作者：
Hagerman, Randi J.
影响因子：
--
作者：
Garrett, AS;Menon, V;Reiss, AL
通讯作者：
Reiss, AL