The Arabidopsis lyrata genome sequence and the basis of rapid genome size change.
The Arabidopsis lyrata genome sequence and the basis of rapid genome size change.
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我们报道了异交拟南芥的207 Mb基因组序列，该基因组与自交种A. thaliana thaliana大约10 million百万years前.一般认为，小得多的A.只有125 Mb的拟南芥基因组构成了该家族的衍生状态。该属中明显的基因组减少可以部分归因于大规模重排导致的DNA丢失，但主要原因在于整个基因组中发现的数十万个小缺失。这些基因主要存在于非编码DNA和转座子中，但编码蛋白质的多基因家族在A. Thaliana也是。分析了A.拟南芥表明DNA丢失的过程正在进行中，这表明对较小基因组的普遍选择。
We present the 207 Mb genome sequence of the outcrosser Arabidopsis lyrata, which diverged from the self-fertilizing species A. thaliana about 10 million years ago. It is generally assumed that the much smaller A. thaliana genome, which is only 125 Mb, constitutes the derived state for the family. Apparent genome reduction in this genus can be partially attributed to the loss of DNA from large-scale rearrangements, but the main cause lies in the hundreds of thousands of small deletions found throughout the genome. These occurred primarily in non-coding DNA and transposons, but protein-coding multi-gene families are smaller in A. thaliana as well. Analysis of deletions and insertions still segregating in A. thaliana indicates that the process of DNA loss is ongoing, suggesting pervasive selection for a smaller genome.
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