High concentrations of pharmaceuticals emerging as a threat to Himalayan water sustainability.
High concentrations of pharmaceuticals emerging as a threat to Himalayan water sustainability.
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DOI：
10.1007/s11356-021-18302-8
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Brown LE
中科院分区：
文献类型：
--
作者：
Quincey DJ;Kay P;Wilkinson J;Carter LJ;Brown LE
第六个联合国可持续发展目标，清洁水和环境卫生，直接支持健康，水生命和可持续城市的其他目标。我们强调，恶劣的卫生条件，例如在河流中检测到的一些最高浓度的药物，将放大社会和环境压力，预测气候引起的流量减少。快速发展的城市中心缺乏足够的水处理工程，需要在减少供应成为现实之前优先考虑改善水质。在尼泊尔的加德满都市和安纳普尔纳地区的23条河流中，我们发现了35种受监测的人类使用药物中的28种。在加德满都市（磺胺二甲嘧啶、甲硝唑和环丙沙星）和农村地区（环丙沙星）的本次采样活动中测得的抗生素浓度均超过了预测的无效应浓度，表明这些地点存在抗生素耐药性扩散的风险，并影响其他生态毒理学终点。预计气候导致的流量减少加上受污染的河流系统将扩大未来的社会和环境压力。在线版本包含补充材料，可通过10.1007/s11356-021-18302-8获得。
The sixth UN Sustainable Development Goal, Clean Water and Sanitation, directly underpins other goals of Health, Life in Water and Sustainable Cities. We highlight that poor sanitation, exemplified through some of the highest concentrations of pharmaceuticals ever detected in rivers, will amplify societal and environmental stress where climate-induced reductions in flow are predicted. Rapidly growing urban centres with inadequate water treatment works will need to prioritise water quality improvement before supply reductions become a reality. For 23 river locations within Kathmandu City and the Annapurna region, Nepal, we show the presence of 28 of 35 monitored human-use pharmaceuticals. Concentrations of antibiotics measured in this sampling campaign in both Kathmandu City (sulfamethazine, metronidazole and ciprofloxacin) and rural locations (ciprofloxacin) are in excess of predicted no effect concentrations, suggesting these sites are at risk of proliferating antimicrobial resistance as well as affecting other ecotoxicological endpoints. It is anticipated that climate-induced reductions in flow combined with contaminated river systems will amplify future societal and environmental stress. The online version contains supplementary material available at 10.1007/s11356-021-18302-8.
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