The Neutralizing Antibody Response against Severe Acute Respiratory Syndrome Coronavirus 2 and the Cytokine/Chemokine Release in Patients with Different Levels of Coronavirus Diseases 2019 Severity: Cytokine Storm Still Persists Despite Viral Disappearance in Critical Patients.
The Neutralizing Antibody Response against Severe Acute Respiratory Syndrome Coronavirus 2 and the Cytokine/Chemokine Release in Patients with Different Levels of Coronavirus Diseases 2019 Severity: Cytokine Storm Still Persists Despite Viral Disappearance in Critical Patients.
复制标题
DOI：
10.31662/jmaj.2020-0083
复制
发表时间：
2021-01-29
期刊：
影响因子：
--
通讯作者：
Mori Y
中科院分区：
文献类型：
--
作者：
Tjan LH;Nagano T;Furukawa K;Nishimura M;Arii J;Fujinaka S;Iwata S;Sano S;Tohma Y;Nishimura Y;Mori Y
2019冠状病毒病（COVID-19）患者表现出广泛的临床谱，从轻微的呼吸道症状到危重和致命疾病，已知老年人受到的影响更严重。这种现象的潜在机制尚不清楚。众所周知，针对病毒的中和抗体对于消除病毒非常重要。此外，这种抗体在严重COVID-19患者中以高水平诱导，随后病毒复制终止。严重的COVID-19患者表现出高水平的细胞因子/趋化因子，即使在病毒消失后也是如此。这表明细胞因子/趋化因子在疾病严重程度中起重要作用。这些发现还表明，应早期给予抗病毒治疗（单克隆抗体和/或恢复期血浆治疗）以消除病毒，然后在病毒基因组消失后进行类固醇治疗，特别是在症状严重的患者中。
Patients with coronavirus disease 2019 (COVID-19) exhibit a wide clinical spectrum ranging from mild respiratory symptoms to critical and fatal diseases, and older individuals are known to be more severely affected. The underlying mechanism of this phenomenon is unknown. A neutralizing antibody against viruses is known to be important to eliminate the virus. In addition, this antibody is induced at high levels in patients with severe COVID-19, followed by a termination of virus replication. Severe COVID-19 patients exhibit high levels of cytokines/chemokines, even after the disappearance of the virus. This indicates that cytokines/chemokines play significant roles in disease severity. These findings also suggest that antiviral therapy (monoclonal antibody and/or convalescent plasma therapy) should be administered early to eliminate the virus, followed by steroid treatment after viral genome disappearance, especially in patients with severe symptoms.
登录
查看更多内容
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
6.8
作者：
Lin, Chenyao;Xiang, Jie;Shen, Changxin
通讯作者：
Shen, Changxin
影响因子：
13.2
作者：
Xu, Jiuyang;Jia, Wenxu;Zhang, Linqi
通讯作者：
Zhang, Linqi
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
15.9
作者：
Wang, Yanqun;Zhang, Lu;Zhao, Jincun
通讯作者：
Zhao, Jincun