Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection.
Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection.
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DOI：
10.1016/j.bbi.2013.06.009
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发表时间：
2013-11
影响因子：
15.1
通讯作者：
Doyle, William J.
中科院分区：
文献类型：
--
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Turner, Ronald B.;Marsland, Anna L.;Casselbrant, Margaretha L.;Li-Korotky, Ha-Sheng;Epel, Elissa S.;Doyle, William J.
关键词：
研究发现，儿童和青少年时期的社会经济地位（SES）较低可以预测成年人对普通感冒病毒的易感性。在这里，我们测试是否低儿童SES与较短的白细胞端粒长度在成年期，以及端粒长度介导的儿童SES和急性上呼吸道疾病的易感性之间的关联。在基线时，196名健康志愿者报告了他们目前是否拥有自己的房屋，以及他们童年的每一年，他们的父母是否拥有家庭房屋。志愿者还抽血评估攻击病毒的特异性抗体，以及CD8+CD28− T淋巴细胞端粒长度（在一个子集中，n = 135）。随后，他们被隔离在一家酒店，接触一种引起普通感冒的病毒（鼻病毒[RV] 39），并在接触后5天内跟踪感染和疾病（临床感冒）。较低的儿童SES（通过父母拥有房屋的年数较少来衡量）与较短的成人CD8+CD28−端粒长度相关，并且与成年后暴露于普通感冒病毒时发生感染和临床疾病的可能性增加有关。这些协会是独立的成人SES，年龄，性别，种族，体重，神经质，和童年的家庭特征。与感染和感冒的关联也独立于攻毒前病毒特异性抗体和季节。进一步的分析不支持吸烟、饮酒或体力活动的介导作用，但表明CD8+CD28−细胞端粒长度可能是儿童SES与感染和儿童SES与感冒之间关联的部分介导因素。
Low socioeconomic status (SES) during childhood and adolescence has been found to predict greater susceptibility to common cold viruses in adults. Here, we test whether low childhood SES is associated with shorter leukocyte telomere length in adulthood, and whether telomere length mediates the association between childhood SES and susceptibility to acute upper respiratory disease in adulthood. At baseline, 196 healthy volunteers reported whether they currently owned their home and, for each year of their childhood, whether their parents owned the family home. Volunteers also had blood drawn for assessment of specific antibody to the challenge virus, and for CD8+CD28− T-lymphocyte telomere length (in a subset, n = 135). They were subsequently quarantined in a hotel, exposed to a virus (rhinovirus [RV] 39) that causes a common cold and followed for infection and illness (clinical cold) over 5 post-exposure days. Lower childhood SES as measured by fewer years of parental home ownership was associated with shorter adult CD8+CD28− telomere length and with an increased probability of developing infection and clinical illness when exposed to a common cold virus in adulthood. These associations were independent of adult SES, age, sex, race, body mass, neuroticism, and childhood family characteristics. Associations with infections and colds were also independent of pre-challenge viral-specific antibody and season. Further analyses do not support mediating roles for smoking, alcohol consumption or physical activity but suggest that CD8+CD28− cell telomere length may act as a partial mediator of the associations between childhood SES and infection and childhood SES and colds.
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影响因子：
14.2
作者：
Chen, Edith;Hanson, Margaret D.;Miller, Gregory E.
通讯作者：
Miller, Gregory E.
DOI：
10.1111/j.1749-6632.2009.05334.x
发表时间：
2010-01-01
期刊：
BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH
影响因子：
--
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Matthews, Karen A.
通讯作者：
Matthews, Karen A.
影响因子：
4.6
作者：
Boyle, MH
通讯作者：
Boyle, MH
影响因子：
4.2
作者：
Dowd, J. B.;Aiello, A. E.;Alley, D. E.
通讯作者：
Alley, D. E.
影响因子：
7.7
作者：
Ehrlenbach, Silvia;Willeit, Peter;Brandstaetter, Anita
通讯作者：
Brandstaetter, Anita