The evaluation of juvenile ocular hypertension by optical coherence tomography angiography.
The evaluation of juvenile ocular hypertension by optical coherence tomography angiography.
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DOI：
10.1186/s12886-020-01641-4
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发表时间：
2020-10-21
影响因子：
2
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Chen X;Wang X;Hu X;Sun X
本文报道了用光学相干断层扫描血管造影（OCTA）测量老年高眼压患者血管密度（VD）的结果。然而，青少年高眼压症（JOHT）中VD的研究有限。我们希望在JOHT中使用OCTA评估VD变化。我们还研究了眼内压（IOP）和垂直杯/盘比（CDR）的潜在风险参数，以观察JOHT的发展。我们在复旦大学附属眼耳鼻喉科医院青光眼门诊使用OCTA检查了45名对照组（Ctrl）受试者的86只眼和34名JOHT患者的65只眼。比较对照组和JOHT组放射状视乳头周围毛细血管（RPC）和中心凹周围浅血管丛（SVP）的VD。其他基本研究因素如年龄、性别、血压、最佳矫正视力、中央角膜厚度、IOP、CDR、视网膜神经纤维层厚度、神经节细胞复合体、视野平均差和模式标准差也被记录。对照组和JOHT组鼻下和颞侧RPC-VD差异无统计学意义（P> 0.05），而SVP-VD差异无统计学意义（P > 0.05）。在混合线性回归模型分析中，时间RPC-VD与高IOP呈轻微负相关（r =-1.379，P = 0.043）。鼻侧、鼻侧、颞侧、颞上、鼻上5个断面的RPC-VD与大CDR呈正相关（均P < 0.05）。上级和鼻部区域的SVP-VD与高IOP呈轻微负相关（r =-1.877，P = 0.023; r =-1.693，P = 0.049）。其他地区眼压、CDR与VD的关系无统计学差异。JOHT受试者的鼻下和颞乳头周围VD略低。关于IOP和CDR的参数，视乳头周围颞部VD与IOP> 21 mmHg呈临界负相关，而另外5个区域与大CDR呈强正相关。部分黄斑区仅与高眼压参数呈边缘性正相关。我们的结论是，OCTA可以作为一种潜在的技术来评估的VD在JOHT和视乳头周围扫描应单独分析的基础上，不同水平的CDR。
Vessel density (VD) of the elderly ocular hypertension patients measured by optical coherence tomography angiography (OCTA) have been reported. However, the studies of VD in juvenile ocular hypertension (JOHT) are limited. We wished to evaluate VD changes using OCTA in JOHT. We also investigated the potential risk parameters of intraocular pressure (IOP) and vertical cup/disc ratio (CDR) with OCTA for observing the development of JOHT. We examined 86 eyes in 45 control (Ctrl) subjects and 65 eyes in 34 patients with JOHT using OCTA at the glaucoma clinic of the Eye, Ear, Nose, and Throat Hospital of Fudan University. The VD of radial peripapillary capillaries (RPC) and the perifoveal superficial vascular plexus (SVP) was compared between the Ctrl and JOHT groups. Other basic study factors such as age, sex, blood pressure, best-corrected visual acuity, central corneal thickness, IOP, CDR, the thickness of the retinal nerve fiber layer, ganglion cell complex, visual field mean deviation, and pattern standard deviation were also recorded. Bare difference was found in the nasal-inferior and temporal RPC-VD between the Ctrl and JOHT groups (P = 0.042 and P = 0.033, respectively) while SVP-VD was not (all P > 0.05). In the mixed linear regression model analysis, temporal RPC-VD was marginally negatively associated with high IOP (r = − 1.379, P = 0.043). Five additional sections of nasal, inferior-nasal, inferior-temporal, superior-temporal, and superior-nasal RPC-VD showed positive correlation with large CDR (all P < 0.05). SVP-VD in the superior and nasal regions was marginally negatively correlated with high IOP (r = − 1.877, P = 0.023; r = − 1.693, P = 0.049). No other regions were found statistical different of relationship between IOP, CDR and VD. Nasal-inferior and temporal peripapillary VD was marginally lower in JOHT subjects. Regarding parameters of IOP and CDR, peripapillary temporal VD had a borderline level of negative correlation with IOP more than 21 mmHg while additional five regions were strongly positively correlated with large CDR. Some macular regions only found marginal positive correlation with parameter of high IOP. We conclude that OCTA can be used as a potential technique to evaluate the VD in JOHT and peripapillary scans should be analyzed individually based on different levels of CDR.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
DOI：
10.1001/jama.2014.3192
发表时间：
2014-05-14
期刊：
JAMA
影响因子：
--
作者：
Weinreb RN;Aung T;Medeiros FA
通讯作者：
Medeiros FA
影响因子：
4.4
作者：
Triolo, Giacinto;Rabiolo, Alessandro;Bandello, Francesco
通讯作者：
Bandello, Francesco
影响因子：
4.1
作者：
Ventura, ACS;Böhnke, M;Mojon, DS
通讯作者：
Mojon, DS
DOI：
10.1007/s00417-015-3095-y
发表时间：
2015-09-01
影响因子：
2.7
作者：
Wang, Xiaolei;Jiang, Chunhui;Sun, Xinghuai
通讯作者：
Sun, Xinghuai