Threat-anticipatory psychophysiological response is enhanced in youth with anxiety disorders and correlates with prefrontal cortex neuroanatomy.
Threat-anticipatory psychophysiological response is enhanced in youth with anxiety disorders and correlates with prefrontal cortex neuroanatomy.
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DOI：
10.1503/jpn.200110
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发表时间：
2021-03-11
期刊：
影响因子：
--
通讯作者：
Pine DS
中科院分区：
文献类型：
--
作者：
Abend R;Bajaj MA;Harrewijn A;Matsumoto C;Michalska KJ;Necka E;Palacios-Barrios EE;Leibenluft E;Atlas LY;Pine DS
威胁预期涉及神经回路，该神经回路已进化为促进防御行为；该电路的扰动可能会产生过度的威胁预期反应，这是病理性焦虑的一个关键特征。对青少年此类机制的研究面临伦理和实践的限制。在这里，我们使用热刺激来引发疼痛预期心理生理反应，并绘制其与焦虑青少年和健康青少年大脑结构的相关性。患有焦虑症的青少年 (n = 25) 和健康的青少年 (n = 25) 完成了一项受指导的威胁预期任务，其中提示预测无痛或疼痛的热刺激；我们使用皮肤电导反应对疼痛预期和体验过程中的心理生理反应进行索引。另一次访问中收集的 41 名参与者的高分辨率大脑结构成像数据可用。分析测试了两组基于心理生理线索的疼痛预期和疼痛体验反应是否存在差异。然后进行分析，将心理生理反应强度映射到大脑结构。患有焦虑症的青少年表现出增强的心理生理反应，特别是在预期疼痛刺激时（b = 0.52，p = 0.003）。在整个样本中，心理生理预期反应的强度与背外侧前额叶皮层的厚度呈负相关（pFWE < 0.05）；对热刺激的心理生理反应与后岛叶的厚度呈正相关（pFWE < 0.05）。局限性包括样本量较小和横截面设计。这些发现表明，威胁预期心理生理反应将患有焦虑症的青少年与健康青少年区分开来，并且它们将大脑结构与疼痛预期和体验过程中的心理生理反应联系起来。焦虑研究中对威胁预期的关注可以描绘出相关的神经回路。
Threat anticipation engages neural circuitry that has evolved to promote defensive behaviours; perturbations in this circuitry could generate excessive threat-anticipation response, a key characteristic of pathological anxiety. Research into such mechanisms in youth faces ethical and practical limitations. Here, we use thermal stimulation to elicit pain-anticipatory psychophysiological response and map its correlates to brain structure among youth with anxiety and healthy youth. Youth with anxiety (n = 25) and healthy youth (n = 25) completed an instructed threat-anticipation task in which cues predicted nonpainful or painful thermal stimulation; we indexed psychophysiological response during the anticipation and experience of pain using skin conductance response. High-resolution brain-structure imaging data collected in another visit were available for 41 participants. Analyses tested whether the 2 groups differed in their psychophysiological cue-based pain-anticipatory and pain-experience responses. Analyses then mapped psychophysiological response magnitude to brain structure. Youth with anxiety showed enhanced psychophysiological response specifically during anticipation of painful stimulation (b = 0.52, p = 0.003). Across the sample, the magnitude of psychophysiological anticipatory response correlated negatively with the thickness of the dorsolateral prefrontal cortex (pFWE < 0.05); psychophysiological response to the thermal stimulation correlated positively with the thickness of the posterior insula (pFWE < 0.05). Limitations included the modest sample size and the cross-sectional design. These findings show that threat-anticipatory psychophysiological response differentiates youth with anxiety from healthy youth, and they link brain structure to psychophysiological response during pain anticipation and experience. A focus on threat anticipation in research on anxiety could delineate relevant neural circuitry.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
9.2
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
17.7
作者：
Gold, Andrea L.;Abend, Rany;Britton, Jennifer C.;Behrens, Brigid;Farber, Madeline;Ronkin, Emily;Chen, Gang;Leibenluft, Ellen;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
1.7
作者：
Beesdo, Katja;Knappe, Susanne;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
10.6
作者：
Grillon, C
通讯作者：
Grillon, C