Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.
Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.
复制标题
DOI：
10.1176/appi.ajp.2019.19060650
复制
发表时间：
2020-05-01
影响因子：
17.7
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Gold, Andrea L.;Abend, Rany;Britton, Jennifer C.;Behrens, Brigid;Farber, Madeline;Ronkin, Emily;Chen, Gang;Leibenluft, Ellen;Pine, Daniel S.
虽然儿童和成人焦虑症患者对威胁的神经反应相似，但在一些功能磁共振成像(FMRI)研究中发现了与年龄相关的差异。为了协调不同的发现，作者比较了患有焦虑症和不患有焦虑症的年轻人和成年人的大脑功能，同时对恐惧和对模糊威胁的记忆进行了评级。200名年龄在8-50岁之间的未服用药物的人接受了评估，其中包括93名患有焦虑症的参与者。参与者在诊所接受了歧视性威胁、条件反射和消亡。大约3周后，他们完成了一项涉及灭绝回忆的fMRI范式，在这个范式中，他们评估了他们对变形刺激引起的恐惧水平，以及他们对与消失的威胁线索不同程度的相似程度的外显记忆。年龄缓和了两组焦虑症的研究结果。首先，随着年龄的增长，与患有焦虑症的参与者相比，健康受试者在处理与威胁相关的线索时，表现出更大的杏仁核-前额叶腹内侧皮质(VmPFC)连接。其次，年龄通过不同注意力和大脑区域的不同方式缓和了诊断激活的差异。在对恐惧进行评级时，在年龄相对较大的焦虑组和健康组之间，vmPFC的激活情况有所不同。相比之下，当对任务刺激的记忆进行评级时，焦虑组和健康组下颞叶皮质的激活在相对较年轻的年龄时有所不同。与之前证明焦虑症的生物学相关性与年龄相关的相似性的研究相反，这项研究确定了年龄差异。这些发现可能反映了这项研究对相对较晚成熟的心理过程的关注，特别是对模糊威胁的评估和外显记忆，并为焦虑的神经发育角度提供了信息。
Although both pediatric and adult patients with anxiety disorders exhibit similar neural responding to threats, age-related differences have been found in some functional MRI (fMRI) studies. To reconcile disparate findings, the authors compared brain function in youths and adults with and without anxiety disorders while rating fear and memory of ambiguous threats. Two hundred medication-free individuals ages 8–50 were assessed, including 93 participants with an anxiety disorder. Participants underwent discriminative threat conditioning and extinction in the clinic. Approximately 3 weeks later, they completed an fMRI paradigm involving extinction recall, in which they rated their levels of fear evoked by, and their explicit memory for, morph stimuli with varying degrees of similarity to the extinguished threat cues. Age moderated two sets of anxiety disorder findings. First, as age increased, healthy subjects compared with participants with anxiety disorders exhibited greater amygdala-ventromedial prefrontal cortex (vmPFC) connectivity when processing threat-related cues. Second, age moderated diagnostic differences in activation in ways that varied with attention and brain regions. When rating fear, activation in the vmPFC differed between the anxiety and healthy groups at relatively older ages. In contrast, when rating memory for task stimuli, activation in the inferior temporal cortex differed between the anxiety and healthy groups at relatively younger ages. In contrast to previous studies that demonstrated age-related similarities in the biological correlates of anxiety disorders, this study identified age differences. These findings may reflect this study’s focus on relatively late-maturing psychological processes, particularly the appraisal and explicit memory of ambiguous threat, and inform neurodevelopmental perspectives on anxiety.
登录
查看更多内容
影响因子：
2.2
作者：
Meyer A;Hajcak G;Torpey-Newman D;Kujawa A;Olino TM;Dyson M;Klein DN
通讯作者：
Klein DN
影响因子：
1.7
作者：
Beesdo, Katja;Knappe, Susanne;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
4.7
作者：
Haller SP;Kircanski K;Stoddard J;White LK;Chen G;Sharif-Askary B;Zhang S;Towbin KE;Pine DS;Leibenluft E;Brotman MA
通讯作者：
Brotman MA
影响因子：
2.9
作者：
Ganella, Despina E.;Barendse, Marjolein E. A.;Whittle, Sarah
通讯作者：
Whittle, Sarah
DOI：
10.1073/pnas.1400335111
发表时间：
2014-02-25
影响因子：
11.1
作者：
LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.